Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Article Details
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Clark JK, Cowley P, Muir AW, Palin R, Pow E, Prosser AB, Taylor R, Zhang MQ
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Bioorg Med Chem Lett. 2002 Sep 16;12(18):2565-8.
- PubMed ID
- 12182861 [ View in PubMed]
- Abstract
A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. Several potent reversal agents have been identified and their haemodynamic effects measured.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Donepezil Acetylcholinesterase EC 50 (nM) 43 N/A N/A Details Donepezil Acetylcholinesterase IC 50 (nM) 18 N/A N/A Details Huperzine B Acetylcholinesterase IC 50 (nM) 30 N/A N/A Details Huperzine B Acetylcholinesterase EC 50 (nM) 19 N/A N/A Details Zanapezil Acetylcholinesterase EC 50 (nM) 1140 N/A N/A Details