Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.

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Kalgutkar AS, Rowlinson SW, Crews BC, Marnett LJ

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):521-4.

PubMed ID

11844663 [ View in PubMed

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Abstract

This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Meclofenamic acid	Prostaglandin G/H synthase 2	IC 50 (nM)	40	N/A	N/A	Details