(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.

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Sun LQ, Takaki K, Chen J, Bertenshaw S, Iben L, Mahle CD, Ryan E, Wu D, Gao Q, Xu C

(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1345-9.

PubMed ID

15713384 [ View in PubMed

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Abstract

(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives (e.g., 3 and 4) were synthesized as novel melatoninergic ligands with significantly lower vasoconstrictive activity in vitro in the rat tail artery. Binding affinity assays were performed on cloned human MT1 and MT2 receptors stably expressed in NIH3T3 cells.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Melatonin	Melatonin receptor type 1A	Ki (nM)	0.3	N/A	N/A	Details
Melatonin	Melatonin receptor type 1B	Ki (nM)	0.7	N/A	N/A	Details