Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.
Article Details
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Boschelli DH, Powell D, Golas JM, Boschelli F
Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.
Bioorg Med Chem Lett. 2003 Sep 15;13(18):2977-80.
- PubMed ID
- 12941315 [ View in PubMed]
- Abstract
4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b]quinolines are much less effective Src inhibitors.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Bosutinib Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 100 N/A N/A Details Bosutinib Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 1.2 N/A N/A Details