Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.

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Boschelli DH, Powell D, Golas JM, Boschelli F

Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):2977-80.

PubMed ID

12941315 [ View in PubMed

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Abstract

4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b]quinolines are much less effective Src inhibitors.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Bosutinib	Proto-oncogene tyrosine-protein kinase Src	IC 50 (nM)	100	N/A	N/A	Details
Bosutinib	Proto-oncogene tyrosine-protein kinase Src	IC 50 (nM)	1.2	N/A	N/A	Details