Proto-oncogene tyrosine-protein kinase Src

BE0000838ProteinHumansSRC

Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as... It is acted on by 72 drugs in DrugBank.

Gene name
SRC
UniProtKB entry
P12931Swiss-Prot
Cellular location
Cell membrane
Residues / weight
536 residues · 59,834 Da
Also known as
2.7.10.2 · p60-Src · pp60c-src · Proto-oncogene c-Src · SRC1

Resolves to

Protein
UniProtP12931UniProt nameSRC_HUMAN
Gene
HGNCHGNC:11283NCBI Gene6714GenBank10635153GeneCardsSRC
Pharmacology
IUPHAR/GtoPdb2206KEGGhsa:6714
Structure
PDB1A07PDB1A08PDB1A09
Drugs

What you can answer from here — as of September 07, 2019

72DrugsApproved to experimental, with action, bond type and pharmacological action
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29Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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251+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proto-oncogene tyrosine-protein kinase Src, how selective are they, and which programs against it are still in active trials?

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