Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors.
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Boschelli DH, Wang D, Wang Y, Wu B, Honores EE, Barrios Sosa AC, Chaudhary I, Golas J, Lucas J, Boschelli F
Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors.
Bioorg Med Chem Lett. 2010 May 1;20(9):2924-7. doi: 10.1016/j.bmcl.2010.03.025. Epub 2010 Mar 7.
- PubMed ID
- 20363128 [ View in PubMed]
- Abstract
The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC(50) values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Bosutinib Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 100 N/A N/A Details Bosutinib Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 3.8 N/A N/A Details