Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.

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Ishikawa M, Hashimoto Y

Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.

J Med Chem. 2011 Mar 24;54(6):1539-54. doi: 10.1021/jm101356p. Epub 2011 Feb 23.

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21344906 [ View in PubMed

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
beta-Naphthoflavone	Aryl hydrocarbon receptor	EC 50 (nM)	1400	N/A	N/A	Details