Aryl hydrocarbon receptor

BE0003721ProteinHumansAHR

Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467,... It is acted on by 39 drugs in DrugBank.

Gene name
AHR
UniProtKB entry
P35869Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
848 residues · 96,147 Da
Also known as
Ah receptor · AhR · BHLHE76 · Class E basic helix-loop-helix protein 76

Resolves to

Protein
UniProtP35869UniProt nameAHR_HUMAN
Gene
HGNCHGNC:348NCBI Gene196GenBank533324GeneCardsAHR
Pharmacology
IUPHAR/GtoPdb2951KEGGhsa:196
Structure
PDB5NJ8PDB7ZUBPDB8QMO
Drugs

What you can answer from here — as of September 07, 2019

39DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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92+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aryl hydrocarbon receptor, how selective are they, and which programs against it are still in active trials?

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