beta-Naphthoflavone

DB06732ExperimentalSmall molecule

β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent.

Chemical structure of beta-Naphthoflavone
Formula / weight
C19H12O2 · 272.2974 g/mol (avg)
Also known as
5,6-benzoflavone · beta-NF · β-NF
Code names
NSC-136015

Resolves to

Compound
UNII1BT0256Y8OCAS6051-87-2ChEMBLCHEMBL26260ChEBI77013PubChem2361
Structure
InChIKeyOUGIDAPQYNCXRA-UHFFFAOYSA-NSMILESO=C1C=C(OC2=C1C1=CC=CC=C1C=C2)C1=CC=CC=C1
Targets
P03372ESR1P11474ESRRAP10589NR2F1P35869AHRQ16678CYP1B1

What you can answer from here — as of June 30, 2022

5Protein targetsEach mapped to UniProt, with action and pharmacological action
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183Drug interactionsStructured to mechanism, not free text
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14+ReferencesStructured and connected to the statements they support
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Which drugs share a target with beta-Naphthoflavone, and which of those have an active Phase 3 trial?

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