A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

Article Details

Citation

Robl JA, Sulsky R, Sun CQ, Simpkins LM, Wang T, Dickson JK Jr, Chen Y, Magnin DR, Taunk P, Slusarchyk WA, Biller SA, Lan SJ, Connolly F, Kunselman LK, Sabrah T, Jamil H, Gordon D, Harrity TW, Wetterau JR

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

J Med Chem. 2001 Mar 15;44(6):851-6.

PubMed ID
11300866 [ View in PubMed
]
Abstract

A series of benzimidazole-based analogues of the potent MTP inhibitor BMS-201038 were discovered. Incorporation of an unsubstituted benzimidazole moiety in place of a piperidine group afforded potent inhibitors of MTP in vitro which were weakly active in vivo. Appropriate substitution on the benzimidazole ring, especially with small alkyl groups, led to dramatic increases in potency, both in a cellular assay of apoB secretion and especially in animal models of cholesterol lowering. The most potent in this series, 3g (BMS-212122), was significantly more potent than BMS-201038 in reducing plasma lipids (cholesterol, VLDL/LDL, TG) in both hamsters and cynomolgus monkeys.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
LomitapideMicrosomal triglyceride transfer protein large subunitIC 50 (nM)0.8N/AN/ADetails
LomitapideMicrosomal triglyceride transfer protein large subunitIC 50 (nM)8N/AN/ADetails