5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

Article Details

Citation

Copy to clipboard

Sulsky R, Robl JA, Biller SA, Harrity TW, Wetterau J, Connolly F, Jolibois K, Kunselman L

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70.

PubMed ID

15380200 [ View in PubMed

]

Abstract

5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Lomitapide	Microsomal triglyceride transfer protein large subunit	IC 50 (nM)	8	N/A	N/A	Details