Physiology of iron metabolism.

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Waldvogel-Abramowski S, Waeber G, Gassner C, Buser A, Frey BM, Favrat B, Tissot JD

Physiology of iron metabolism.

Transfus Med Hemother. 2014 Jun;41(3):213-21. doi: 10.1159/000362888. Epub 2014 May 12.

PubMed ID

25053935 [ View in PubMed

]

Abstract

A revolution occurred during the last decade in the comprehension of the physiology as well as in the physiopathology of iron metabolism. The purpose of this review is to summarize the recent knowledge that has accumulated, allowing a better comprehension of the mechanisms implicated in iron homeostasis. Iron metabolism is very fine tuned. The free molecule is very toxic; therefore, complex regulatory mechanisms have been developed in mammalian to insure adequate intestinal absorption, transportation, utilization, and elimination. 'Ironomics' certainly will be the future of the understanding of genes as well as of the protein-protein interactions involved in iron metabolism.

DrugBank Data that Cites this Article

Drugs

Ferrous sulfate anhydrous

Ferric cation

Tetraferric tricitrate decahydrate

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ferric cation	Transferrin receptor protein 1	Protein	Humans	Yes	Agonist	Details
Tetraferric tricitrate decahydrate	Transferrin receptor protein 1	Protein	Humans	Yes	Ligand	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Tetraferric tricitrate decahydrate	Cytochrome b reductase 1	Protein	Humans	Unknown	Substrate	Details

Drug Reactions

Reaction
Tetraferric tricitrate decahydrate DB14520 Cytochrome b reductase 1 Ferrous cation DB14510	Details