Propranolol metabolism in normal subjects: association with sex steroid hormones.

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Walle T, Walle K, Mathur RS, Palesch YY, Conradi EC

Propranolol metabolism in normal subjects: association with sex steroid hormones.

Clin Pharmacol Ther. 1994 Aug;56(2):127-32.

PubMed ID

8062488 [ View in PubMed

]

Abstract

The objective of this study was to determine the potential role of circulating testosterone and estradiol in regulation of the activity of the sex-dependent pathways of propranolol metabolism (i.e., alpha-naphthoxylactic acid and propranolol glucuronide). The pharmacokinetics of a single 80 mg oral dose of propranolol and the plasma levels of the sex steroid hormones were therefore determined in normal volunteers. In 33 young men there was a positive correlation between the testosterone levels and the propranolol clearances through both alpha-naphthoxylactic acid (p < 0.001) and propranolol glucuronide (p < 0.002), as well as the total clearance (p < 0.05), but not through aromatic ring hydroxylation. Testosterone cypionate administration led to an increased clearance of propranolol through alpha-naphthoxylactic acid in nine of the 11 men studied, further supporting a stimulatory effect of testosterone on propranolol metabolism. In 23 young women there was no significant association between the circulating levels of either estradiol or testosterone and any of the clearances of propranolol. These observations may be clinically relevant for propranolol therapy and may provide improved insight into the influence of gender and circulating gonadal hormones on drug metabolism in humans.

DrugBank Data that Cites this Article

Drugs

Propranolol

Drug Reactions

Reaction
Propranolol DB00571 Propranolol Glucuronide DBMET02586	Details
Propranolol DB00571 α-Naphthoxylactic Acid DBMET02587	Details

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
Integrate drug-drug interactions in your software
Propranolol Testosterone	Testosterone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Propranolol Testosterone propionate	Testosterone propionate may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Propranolol 1-Testosterone	1-Testosterone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Propranolol 4-Hydroxytestosterone	4-Hydroxytestosterone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Propranolol Dehydrochloromethyltestosterone	Dehydrochloromethyltestosterone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.