Drug-Induced Serotonin Syndrome.
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Bartlett D
Drug-Induced Serotonin Syndrome.
Crit Care Nurse. 2017 Feb;37(1):49-54. doi: 10.4037/ccn2017169.
- PubMed ID
- 28148614 [ View in PubMed]
- Abstract
Serotonin syndrome is a potentially fatal condition caused by drugs that affect serotonin metabolism or act as serotonin receptor agonists. Monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors are the medications most commonly associated with serotonin syndrome. Serotonin syndrome can be mild and of short duration, but a prolonged course, life-threatening complications, and death are possible. Detection of serotonin syndrome is not difficult if the diagnostic criteria are understood and properly used, but the syndrome has no confirmatory tests and other drug-induced syndromes can, to a degree, mimic serotonin syndrome. The treatment is symptomatic and supportive. Antidotal therapies are available, but the evidence for their effectiveness is limited. If serotonin syndrome is promptly identified and aggressively treated, the patient should fully recover.
DrugBank Data that Cites this Article
- Drugs
- Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareEscitalopramRotigotine The risk or severity of serotonin syndrome can be increased when Rotigotine is combined with Escitalopram. EscitalopramMirtazapine The risk or severity of serotonin syndrome can be increased when Mirtazapine is combined with Escitalopram. EscitalopramMorphine The risk or severity of serotonin syndrome can be increased when Morphine is combined with Escitalopram. EscitalopramCodeine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Escitalopram. EscitalopramHydromorphone The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Escitalopram.