Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions.
Article Details
- CitationCopy to clipboard
Meyer UA
Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions.
Yale J Biol Med. 1996 May-Jun;69(3):203-9.
- PubMed ID
- 9165689 [ View in PubMed]
- Abstract
Omeprazole, lansoprazole and pantoprazole are metabolized by several human cytochromes P450, most prominently by CYP2C19 and CYP3A4. Only pantoprazole is also metabolized by a sulfotransferase. Differences in the quantitative contribution of these enzymes and in the relative affinities of the substrates explain some of the observed interactions with carbamazepin, diazepam, phenytoin and theophylline and of the impact of the CYP2C19 (mephenytoin) genetic polymorphism. Of these drugs, pantoprazole has the lowest potential for interactions, both in vitro and in human volunteer studies.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Pantoprazole Cytochrome P450 2C19 Protein Humans UnknownSubstrateInhibitorDetails Pantoprazole Cytochrome P450 3A4 Protein Humans UnknownSubstrateDetails - Drug Reactions
Reaction Details Details Details
