Cytochrome P450 3A4

Details

Name
Cytochrome P450 3A4
Synonyms
  • 1,4-cineole 2-exo-monooxygenase
  • 1,8-cineole 2-exo-monooxygenase
  • 1.14.14.1
  • Albendazole monooxygenase (sulfoxide-forming)
  • Albendazole sulfoxidase
  • Cholesterol 25-hydroxylase
  • CYP3A3
  • CYPIIIA3
  • CYPIIIA4
  • Cytochrome P450 3A3
  • Cytochrome P450 HLp
  • Cytochrome P450 NF-25
  • Cytochrome P450-PCN1
  • Nifedipine oxidase
  • Quinine 3-monooxygenase
Gene Name
CYP3A4
UniProtKB Entry
P08684Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0021936|Cytochrome P450 3A4
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
Number of residues
503
Molecular Weight
57342.67
Theoretical pI
8.25
GO Classification
Functions
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity / 1,8-cineole 2-exo-monooxygenase activity / anandamide 11,12 epoxidase activity / anandamide 14,15 epoxidase activity / anandamide 8,9 epoxidase activity / estrogen 16-alpha-hydroxylase activity / estrogen 2-hydroxylase activity / retinoic acid 4-hydroxylase activity
Processes
aflatoxin metabolic process / cholesterol metabolic process / estrogen metabolic process / lipid hydroxylation / long-chain fatty acid biosynthetic process / retinoic acid metabolic process / retinol metabolic process / vitamin D catabolic process / xenobiotic catabolic process
General Function
A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981)
Specific Function
1,8-cineole 2-exo-monooxygenase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
2-22
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0021937|Cytochrome P450 3A4 (CYP3A4)
ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG
CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG
CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT
GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT
GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT
GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA
GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA
AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG
AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC
ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA
GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT
CTCTCAATAATCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTT
CCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTC
GAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCA
AAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATC
TTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTG
GCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAAT
AAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAAT
GAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTT
GAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTT
CACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAG
AAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAAC
TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG
AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGA
CTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGT
GGAGCCTGA
Chromosome Location
7
Locus
7q22.1
External Identifiers
ResourceLink
UniProtKB IDP08684
UniProtKB Entry NameCP3A4_HUMAN
GenBank Gene IDM18907
GeneCard IDCYP3A4
GenAtlas IDCYP3A4
HGNC IDHGNC:2637
PDB ID(s)1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4D6Z, 4D75, 4D78, 4D7D, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R, 5G5J, 5TE8, 5VC0, 5VCC, 5VCD, 5VCE, 5VCG, 6BCZ, 6BD5, 6BD6, 6BD7, 6BD8, 6BDH, 6BDI, 6BDK, 6BDM, 6OO9, 6OOA, 6OOB, 7KS8, 7KSA, 7KVH, 7KVI, 7KVJ, 7KVK, 7KVM, 7KVN, 7KVO, 7KVP, 7KVQ, 7KVS, 7LXL, 7UAY, 7UAZ, 7UF9, 7UFA, 7UFB, 7UFC, 7UFD, 7UFE, 7UFF, 8DYC, 8EWD, 8EWE, 8EWL, 8EWM, 8EWN, 8EWP, 8EWQ, 8EWR, 8EWS, 8EXB, 8SO1, 8SO2
KEGG IDhsa:1576
IUPHAR/Guide To Pharmacology ID1337
NCBI Gene ID1576
General References
  1. Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5311-5. [Article]
  2. Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA. 1988 Mar;7(2):79-86. [Article]
  3. Beaune PH, Umbenhauer DR, Bork RW, Lloyd RS, Guengerich FP: Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8064-8. [Article]
  4. Spurr NK, Gough AC, Stevenson K, Wolf CR: The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter. Hum Genet. 1989 Jan;81(2):171-4. [Article]
  5. Bork RW, Muto T, Beaune PH, Srivastava PK, Lloyd RS, Guengerich FP: Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J Biol Chem. 1989 Jan 15;264(2):910-9. [Article]
  6. Chen Q, Wu J, Yu Y: [Establishment of transgenic cell line CHL-3A4 and its metabolic activation]. Zhonghua Yu Fang Yi Xue Za Zhi. 1998 Sep;32(5):281-4. [Article]
  7. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001 Mar;11(2):111-21. [Article]
  8. Hsieh KP, Lin YY, Cheng CL, Lai ML, Lin MS, Siest JP, Huang JD: Novel mutations of CYP3A4 in Chinese. Drug Metab Dispos. 2001 Mar;29(3):268-73. [Article]
  9. Komori M, Hashizume T, Ohi H, Miura T, Kitada M, Nagashima K, Kamataki T: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization. J Biochem. 1988 Dec;104(6):912-6. [Article]
  10. Watkins PB, Wrighton SA, Maurel P, Schuetz EG, Mendez-Picon G, Parker GA, Guzelian PS: Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6310-4. [Article]
  11. Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem. 1989 Jun 25;264(18):10388-95. [Article]
  12. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther. 1994 Jul;270(1):414-23. [Article]
  13. Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM, Watkins PB: CYP3A gene expression in human gut epithelium. Pharmacogenetics. 1994 Oct;4(5):247-59. [Article]
  14. Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S: Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. Br J Clin Pharmacol. 1997 Mar;43(3):245-52. [Article]
  15. Zhao XJ, Kawashiro T, Ishizaki T: Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways. Drug Metab Dispos. 1998 Feb;26(2):188-91. [Article]
  16. Miyazawa M, Shindo M, Shimada T: Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. Drug Metab Dispos. 2001 Feb;29(2):200-5. [Article]
  17. Finta C, Zaphiropoulos PG: Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem. 2002 Feb 22;277(8):5882-90. Epub 2001 Nov 28. [Article]
  18. Dauchy S, Dutheil F, Weaver RJ, Chassoux F, Daumas-Duport C, Couraud PO, Scherrmann JM, De Waziers I, Decleves X: ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. J Neurochem. 2008 Dec;107(6):1518-28. doi: 10.1111/j.1471-4159.2008.05720.x. [Article]
  19. Agarwal V, Kommaddi RP, Valli K, Ryder D, Hyde TM, Kleinman JE, Strobel HW, Ravindranath V: Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite. PLoS One. 2008 Jun 11;3(6):e2337. doi: 10.1371/journal.pone.0002337. [Article]
  20. Pabarcus MK, Hoe N, Sadeghi S, Patterson C, Wiertz E, Correia MA: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Arch Biochem Biophys. 2009 Mar 1;483(1):66-74. doi: 10.1016/j.abb.2008.12.001. Epub 2008 Dec 10. [Article]
  21. Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottee L, Bieche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Decleves X, Duyckaerts C, Loriot MA: Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Drug Metab Dispos. 2009 Jul;37(7):1528-38. doi: 10.1124/dmd.109.027011. Epub 2009 Apr 9. [Article]
  22. Honda A, Miyazaki T, Ikegami T, Iwamoto J, Maeda T, Hirayama T, Saito Y, Teramoto T, Matsuzaki Y: Cholesterol 25-hydroxylation activity of CYP3A. J Lipid Res. 2011 Aug;52(8):1509-16. doi: 10.1194/jlr.M014084. Epub 2011 May 16. [Article]
  23. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  24. Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD, Johnson EF: The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. J Biol Chem. 2004 Sep 10;279(37):38091-4. Epub 2004 Jul 16. [Article]
  25. Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H: Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15. [Article]
  26. Sata F, Sapone A, Elizondo G, Stocker P, Miller VP, Zheng W, Raunio H, Crespi CL, Gonzalez FJ: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. Clin Pharmacol Ther. 2000 Jan;67(1):48-56. [Article]
  27. Dai D, Tang J, Rose R, Hodgson E, Bienstock RJ, Mohrenweiser HW, Goldstein JA: Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther. 2001 Dec;299(3):825-31. [Article]
  28. Eiselt R, Domanski TL, Zibat A, Mueller R, Presecan-Siedel E, Hustert E, Zanger UM, Brockmoller J, Klenk HP, Meyer UA, Khan KK, He YA, Halpert JR, Wojnowski L: Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics. 2001 Jul;11(5):447-58. [Article]
  29. Lamba JK, Lin YS, Thummel K, Daly A, Watkins PB, Strom S, Zhang J, Schuetz EG: Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics. 2002 Mar;12(2):121-32. [Article]
  30. Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Cytochrome P450 3A4 (Humans)protein
primary
Cytochrome P450 3A Subfamily (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Pradefovir mesylateinvestigationalunknowntargetDetails
Flunisolideapproved, investigationalunknownenzymesubstrateinducerDetails
CevimelineapprovedunknownenzymesubstrateDetails
Bortezomibapproved, investigationalnoenzymesubstrateDetails
Fluconazoleapproved, investigationalunknownenzymeinhibitorDetails
Dofetilideapproved, investigationalunknownenzymesubstrateDetails
PantoprazoleapprovedunknownenzymesubstrateDetails
Eletriptanapproved, investigationalunknownenzymesubstrateDetails
NelfinavirapprovednoenzymesubstrateinhibitorDetails
IndinavirapprovedunknownenzymesubstrateinhibitorDetails
Lovastatinapproved, investigationalunknownenzymesubstrateDetails
Reboxetineapproved, experimentalunknownenzymesubstrateinhibitorDetails
NevirapineapprovedunknownenzymesubstrateinducerDetails
Ranolazineapproved, investigationalnoenzymesubstrateinhibitorDetails
ZiprasidoneapprovedunknownenzymesubstrateDetails
Isradipineapproved, investigationalunknownenzymesubstrateinhibitorDetails
DisopyramideapprovedunknownenzymesubstrateDetails
Conjugated estrogensapprovednoenzymesubstrateDetails
Etonogestrelapproved, investigationalnoenzymesubstrateDetails
Bupivacaineapproved, investigationalunknownenzymesubstrateDetails
Bexaroteneapproved, investigationalunknownenzymesubstrateinducerDetails
Vindesineapproved, investigationalunknownenzymesubstrateDetails
Gefitinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Dihydroergotamineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Fluorometholoneapproved, investigationalunknownenzymesubstrateinducerDetails
Terfenadineapproved, withdrawnunknownenzymesubstrateinhibitorDetails
Diltiazemapproved, investigationalunknownenzymesubstrateinhibitorDetails
Alfuzosinapproved, investigationalunknownenzymesubstrateDetails
Vinorelbineapproved, investigationalnoenzymesubstrateDetails
Grepafloxacinapproved, investigational, withdrawnunknownenzymesubstrateDetails
MirtazapineapprovedunknownenzymesubstrateinhibitorDetails
AmlodipineapprovednoenzymesubstrateinhibitorDetails
Nimodipineapproved, investigationalunknownenzymesubstrateDetails
Sorafenibapproved, investigationalunknownenzymesubstrateinhibitorDetails
NisoldipineapprovedunknownenzymesubstrateDetails
Eszopicloneapproved, investigationalunknownenzymesubstrateDetails
Alprazolamapproved, illicit, investigationalunknownenzymesubstrateDetails
ZolpidemapprovedunknownenzymesubstrateDetails
Betamethasoneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Loratadineapproved, investigationalnoenzymesubstrateinhibitorDetails
QuinineapprovedunknownenzymesubstrateinhibitorinducerDetails
Dronabinolapproved, illicitnoenzymesubstrateinhibitorDetails
MontelukastapprovedunknownenzymesubstrateDetails
Buspironeapproved, investigationalunknownenzymesubstrateDetails
Darifenacinapproved, investigationalunknownenzymesubstrateDetails
Albendazoleapproved, vet_approvedunknownenzymesubstrateDetails
Lercanidipineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Erlotinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Rofecoxibapproved, investigational, withdrawnunknownenzymesubstrateinducerDetails
Toremifeneapproved, investigationalunknownenzymesubstrateinhibitorDetails
Vincristineapproved, investigationalunknownenzymesubstrateDetails
Bosentanapproved, investigationalunknownenzymesubstrateinducerDetails
VinblastineapprovedunknownenzymesubstrateinhibitorinducerDetails
VoriconazoleapprovedunknownenzymesubstrateinhibitorDetails
Fluticasone propionateapprovedunknownenzymesubstrateinhibitorDetails
EthosuximideapprovedunknownenzymesubstrateDetails
Medroxyprogesterone acetateapproved, investigationalunknownenzymesubstrateinducerDetails
Cisaprideapproved, investigational, withdrawnunknownenzymesubstrateDetails
Rifabutinapproved, investigationalunknownenzymesubstrateinducerDetails
ImatinibapprovednoenzymesubstrateinhibitorDetails
Nicardipineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Testosteroneapproved, investigationalunknownenzymesubstrateinducerDetails
Efavirenzapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Prednisoneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Clofibrateapproved, investigationalunknownenzymesubstrateinducerDetails
Astemizoleapproved, withdrawnunknownenzymesubstrateinhibitorDetails
SimvastatinapprovedunknownenzymesubstrateDetails
Aprepitantapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
GalantamineapprovednoenzymesubstrateDetails
TamoxifenapprovedunknownenzymesubstrateinhibitorinducerDetails
LosartanapprovedunknownenzymesubstrateinhibitorDetails
Midazolamapproved, illicitunknownenzymesubstrateinhibitorDetails
ErgotamineapprovedunknownenzymesubstrateinhibitorDetails
EplerenoneapprovedunknownenzymesubstrateDetails
Amprenavirapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
DelavirdineapprovedunknownenzymesubstrateinhibitorDetails
Nateglinideapproved, investigationalunknownenzymesubstrateDetails
Esomeprazoleapproved, investigationalunknownenzymesubstrateDetails
Hydrocortisoneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Zileutonapproved, investigational, withdrawnunknownenzymesubstrateDetails
Modafinilapproved, investigationalunknownenzymesubstrateinducerDetails
Dolasetronapproved, investigationalunknownenzymesubstrateDetails
ClopidogrelapprovednoenzymesubstrateDetails
Irinotecanapproved, investigationalunknownenzymesubstrateinhibitorDetails
HydrocortamateapprovedunknownenzymeinducerDetails
EtoposideapprovedunknownenzymesubstrateinhibitorinducerDetails
Roxithromycinapproved, investigational, withdrawnnoenzymesubstrateinhibitorDetails
Alfentanilapproved, illicitunknownenzymesubstrateDetails
Fentanylapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
Tadalafilapproved, investigationalnoenzymesubstrateDetails
Diazepamapproved, illicit, investigational, vet_approvedunknownenzymesubstrateinhibitorDetails
Mifepristoneapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
LoperamideapprovedunknownenzymesubstrateinhibitorDetails
DonepezilapprovedunknownenzymesubstrateDetails
Prednisoloneapproved, vet_approvedunknownenzymesubstrateinducerDetails
VardenafilapprovedunknownenzymesubstrateinhibitorDetails
Tacrolimusapproved, investigationalunknownenzymesubstrateDetails
Conivaptanapproved, investigationalunknownenzymesubstrateinhibitorDetails
Sirolimusapproved, investigationalnoenzymesubstrateDetails
Granisetronapproved, investigationalunknownenzymesubstrateDetails
Triazolamapproved, investigationalunknownenzymesubstrateDetails
Ondansetronapproved, withdrawnunknownenzymesubstrateDetails
Tiagabineapproved, investigationalunknownenzymesubstrateDetails
Cocaineapproved, illicitunknownenzymesubstrateDetails
Zonisamideapproved, investigationalunknownenzymesubstrateDetails
Paricalcitolapproved, investigationalunknownenzymesubstrateDetails
Tinidazoleapproved, investigationalunknownenzymesubstrateDetails
Almotriptanapproved, investigationalunknownenzymesubstrateDetails
Buprenorphineapproved, illicit, investigational, vet_approvedunknownenzymesubstrateinhibitorDetails
Tipranavirapproved, investigationalunknownenzymesubstrateinhibitorDetails
SalmeterolapprovedunknownenzymesubstrateDetails
Hydrocodoneapproved, illicit, investigationalunknownenzymesubstrateDetails
Methylprednisoloneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Zaleplonapproved, illicit, investigationalunknownenzymesubstrateDetails
TelithromycinapprovedunknownenzymesubstrateinhibitorDetails
EthinylestradiolapprovedunknownenzymesubstrateDetails
Exemestaneapproved, investigationalunknownenzymesubstrateDetails
Doxorubicinapproved, investigationalnoenzymesubstrateinhibitorDetails
Levobupivacaineapproved, investigationalunknownenzymesubstrateDetails
Letrozoleapproved, investigationalunknownenzymesubstrateDetails
Busulfanapproved, investigationalunknownenzymesubstrateDetails
CinacalcetapprovedunknownenzymesubstrateDetails
Felodipineapproved, investigationalunknownenzymesubstrateDetails
Ketoconazoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
RifampinapprovedunknownenzymeinducerDetails
Nitrendipineapproved, investigationalunknownenzymesubstrateDetails
Oxybutyninapproved, investigationalunknownenzymesubstrateinhibitorDetails
Clonazepamapproved, illicitunknownenzymesubstrateDetails
Atazanavirapproved, investigationalnoenzymesubstrateinhibitorDetails
AtorvastatinapprovednoenzymesubstrateDetails
PimozideapprovedunknownenzymesubstrateDetails
Sibutramineapproved, illicit, investigational, withdrawnunknownenzymesubstrateDetails
ChlorpheniramineapprovedunknownenzymesubstrateDetails
NifedipineapprovedunknownenzymesubstrateinhibitorinducerDetails
Rabeprazoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
Pioglitazoneapproved, investigationalunknownenzymesubstrateinducerDetails
Nefazodoneapproved, withdrawnunknownenzymesubstrateinhibitorDetails
Cilostazolapproved, investigationalunknownenzymesubstrateDetails
Itraconazoleapproved, investigationalnoenzymesubstrateinhibitorDetails
EscitalopramapprovednoenzymesubstrateDetails
Domperidoneapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Clindamycinapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
Bromocriptineapproved, investigational, withdrawnnoenzymesubstrateinhibitorDetails
Lomustineapproved, investigationalunknownenzymeinhibitorDetails
ClarithromycinapprovedunknownenzymesubstrateinhibitorDetails
Estazolamapproved, illicitunknownenzymesubstrateDetails
FinasterideapprovedunknownenzymesubstrateDetails
HalofantrineapprovedunknownenzymesubstrateDetails
BudesonideapprovednoenzymesubstrateinducerDetails
QuetiapineapprovedunknownenzymesubstrateDetails
Levacetylmethadolapproved, investigational, withdrawnunknownenzymesubstrateDetails
Paclitaxelapproved, vet_approvedunknownenzymesubstrateinducerDetails
Saquinavirapproved, investigationalunknownenzymesubstrateinhibitorDetails
Dexamethasoneapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorinducerDetails
Aripiprazoleapproved, investigationalnoenzymesubstrateDetails
Dasatinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
RetapamulinapprovedunknownenzymesubstrateDetails
Sitagliptinapproved, investigationalunknownenzymesubstrateDetails
Lapatinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
DarunavirapprovedunknownenzymesubstrateinhibitorDetails
Sunitinibapproved, investigationalnoenzymesubstrateinhibitorDetails
Posaconazoleapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorDetails
Mibefradilinvestigational, withdrawnunknownenzymesubstrateinhibitorDetails
Troglitazoneapproved, investigational, withdrawnunknownenzymeinducerDetails
LopinavirapprovedunknownenzymesubstrateinhibitorDetails
PranlukastinvestigationalnoenzymesubstrateDetails
Ciclesonideapproved, investigationalnoenzymesubstrateDetails
Alosetronapproved, withdrawnunknownenzymesubstrateDetails
Maravirocapproved, investigationalunknownenzymesubstrateDetails
TiotropiumapprovedunknownenzymesubstrateDetails
SolifenacinapprovednoenzymesubstrateDetails
Metyraponeapproved, investigationalunknownenzymeinhibitorinducerDetails
Palonosetronapproved, investigationalunknownenzymesubstrateDetails
DexloxiglumideinvestigationalunknownenzymesubstrateDetails
Calanolide AinvestigationalunknownenzymesubstrateDetails
Valdecoxibapproved, investigational, withdrawnunknownenzymesubstrateDetails
Sertindoleapproved, investigational, withdrawnunknownenzymesubstrateDetails
PlitidepsininvestigationalunknownenzymesubstrateDetails
TesmilifeneinvestigationalunknownenzymesubstrateinhibitorinducerDetails
MethadoneapprovedunknownenzymesubstrateinhibitorinducerDetails
RifalazilinvestigationalunknownenzymesubstrateDetails
AzimilideinvestigationalunknownenzymesubstrateDetails
Erythromycinapproved, investigational, vet_approvednoenzymesubstrateinhibitorDetails
Etoricoxibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Carbamazepineapproved, investigationalunknownenzymesubstrateinducerDetails
Rimonabantapproved, investigationalunknownenzymesubstrateDetails
Udenafilapproved, investigationalunknownenzymesubstrateDetails
TemsirolimusapprovedunknownenzymesubstrateDetails
AvasimibeinvestigationalunknownenzymeinducerDetails
CapravirineinvestigationalunknownenzymesubstrateDetails
VicrivirocinvestigationalunknownenzymesubstrateDetails
LaquinimodinvestigationalunknownenzymesubstrateDetails
FluvastatinapprovedunknownenzymesubstrateinhibitorDetails
Sildenafilapproved, investigationalunknownenzymesubstrateDetails
CabergolineapprovedunknownenzymesubstrateDetails
Lisurideapproved, investigationalunknownenzymesubstrateDetails
Pergolideapproved, investigational, vet_approved, withdrawnunknownenzymeinhibitorDetails
RotigotineapprovedunknownenzymesubstrateDetails
Cerivastatinapproved, withdrawnunknownenzymesubstrateinhibitorinducerDetails
Clotrimazoleapproved, vet_approvedunknownenzymesubstrateinhibitorinducerDetails
Risperidoneapproved, investigationalunknownenzymesubstrateDetails
Omeprazoleapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorinducerDetails
Selegilineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Halothaneapproved, vet_approvedunknownenzymesubstrateDetails
IfosfamideapprovedunknownenzymesubstrateinhibitorinducerDetails
Miconazoleapproved, investigational, vet_approvedunknownenzymeinhibitorDetails
Meloxicamapproved, vet_approvedunknownenzymesubstrateDetails
Quinidineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Trazodoneapproved, investigationalunknownenzymesubstrateDetails
Fluvoxamineapproved, investigationalunknownenzymesubstrateinhibitorDetails
AmitriptylineapprovedunknownenzymesubstrateDetails
NortriptylineapprovedunknownenzymesubstrateDetails
CitalopramapprovednoenzymesubstrateinhibitorDetails
CyclobenzaprineapprovedunknownenzymesubstrateDetails
Fluoxetineapproved, vet_approvednoenzymesubstrateinhibitorDetails
SertralineapprovedunknownenzymesubstrateinhibitorDetails
Mianserinapproved, investigationalunknownenzymesubstrateDetails
Antipyrineapproved, investigationalunknownenzymesubstrateDetails
Amiodaroneapproved, investigationalnoenzymesubstrateinhibitorDetails
Dapsoneapproved, investigationalunknownenzymesubstrateDetails
Cyclophosphamideapproved, investigationalunknownenzymesubstrateinducerDetails
Trabectedinapproved, investigationalunknownenzymesubstrateDetails
Phenprocoumonapproved, investigationalunknownenzymesubstrateDetails
WarfarinapprovedunknownenzymesubstrateinducerDetails
VenlafaxineapprovedunknownenzymesubstrateDetails
Terbinafineapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
AzelastineapprovedunknownenzymesubstrateinhibitorDetails
Cyclosporineapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorDetails
VerapamilapprovedunknownenzymesubstrateinhibitorDetails
Estradiolapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Progesteroneapproved, vet_approvedunknownenzymesubstrateinducerDetails
CaffeineapprovedunknownenzymesubstrateDetails
Codeineapproved, illicitunknownenzymesubstrateDetails
DextromethorphanapprovedunknownenzymesubstrateDetails
Docetaxelapproved, investigationalunknownenzymesubstrateinhibitorDetails
HaloperidolapprovedunknownenzymesubstrateinhibitorDetails
Lidocaineapproved, vet_approvedunknownenzymesubstrateDetails
Propranololapproved, investigationalunknownenzymesubstrateDetails
Cimetidineapproved, investigationalunknownenzymeinhibitorDetails
Chloramphenicolapproved, vet_approved, withdrawnunknownenzymeinhibitorDetails
Ciprofloxacinapproved, investigationalunknownenzymeinhibitorDetails
NorfloxacinapprovedunknownenzymeinhibitorDetails
Ambrisentanapproved, investigationalunknownenzymesubstrateDetails
Armodafinilapproved, investigationalunknownenzymeinducerDetails
Benzphetamineapproved, illicitunknownenzymesubstrateDetails
BisoprololapprovedunknownenzymesubstrateDetails
Calcitriolapproved, nutraceuticalunknownenzymesubstrateinducerDetails
Chloroquineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Clobazamapproved, illicitnoenzymesubstrateinducerDetails
Clorazepic acidapproved, illicitunknownenzymesubstrateDetails
Digitoxinapproved, investigationalunknownenzymesubstrateDetails
DronedaroneapprovedunknownenzymesubstrateinhibitorDetails
Estrone sulfateapprovedunknownenzymesubstrateDetails
EtravirineapprovedunknownenzymesubstrateinducerDetails
EverolimusapprovedunknownenzymesubstrateDetails
FelbamateapprovedunknownenzymesubstrateinducerDetails
FesoterodineapprovedunknownenzymesubstrateDetails
Flurazepamapproved, illicit, investigationalunknownenzymesubstrateDetails
Flutamideapproved, investigationalunknownenzymesubstrateDetails
Guanfacineapproved, investigationalunknownenzymesubstrateDetails
Ixabepiloneapproved, investigationalunknownenzymesubstrateDetails
Lansoprazoleapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Levonorgestrelapproved, investigationalunknownenzymesubstrateDetails
Mefloquineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Nilotinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Nilvadipineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Oxycodoneapproved, illicit, investigationalunknownenzymesubstrateDetails
PazopanibapprovedunknownenzymesubstrateinhibitorDetails
Pipotiazineapproved, investigationalunknownenzymesubstrateDetails
Praziquantelapproved, investigational, vet_approvednoenzymesubstrateDetails
PrimaquineapprovedunknownenzymesubstrateinhibitorDetails
Dextropropoxypheneapproved, illicit, investigational, withdrawnunknownenzymesubstrateinhibitorDetails
Repaglinideapproved, investigationalunknownenzymesubstrateDetails
RivaroxabanapprovedunknownenzymesubstrateDetails
Romidepsinapproved, investigationalunknownenzymesubstrateDetails
SilodosinapprovedunknownenzymesubstrateDetails
Tamsulosinapproved, investigationalunknownenzymesubstrateDetails
TeniposideapprovedunknownenzymesubstrateinhibitorDetails
Tetracyclineapproved, vet_approved, withdrawnunknownenzymesubstrateinhibitorDetails
TheophyllineapprovedunknownenzymesubstrateDetails
Tolterodineapproved, investigationalunknownenzymesubstrateDetails
TolvaptanapprovedunknownenzymesubstrateDetails
Tramadolapproved, investigationalunknownenzymesubstrateDetails
Trimethoprimapproved, vet_approvedunknownenzymesubstrateDetails
ZopicloneapprovedunknownenzymesubstrateDetails
Aminoglutethimideapproved, investigationalunknownenzymeinducerDetails
Fosphenytoinapproved, investigationalunknownenzymesubstrateinducerDetails
Nafcillinapproved, investigationalunknownenzymeinducerDetails
OxcarbazepineapprovedunknownenzymeinhibitorinducerDetails
Pentobarbitalapproved, investigational, vet_approvedunknownenzymeinducerDetails
Phenobarbitalapproved, investigationalunknownenzymeinducerDetails
Phenytoinapproved, vet_approvednoenzymesubstrateinducerDetails
Primidoneapproved, vet_approvedunknownenzymeinducerDetails
Rifapentineapproved, investigationalunknownenzymesubstrateinducerDetails
ColchicineapprovedunknownenzymesubstrateinhibitorDetails
ErgometrineapprovedunknownenzymesubstrateDetails
Ketamineapproved, vet_approvedunknownenzymesubstrateinducerDetails
MethylergometrineapprovedunknownenzymesubstrateinhibitorDetails
SaxagliptinapprovedunknownenzymesubstrateDetails
Sufentanilapproved, investigationalunknownenzymesubstrateDetails
BicalutamideapprovedunknownenzymesubstrateinhibitorDetails
Desipramineapproved, investigationalunknownenzymeinhibitorDetails
MetronidazoleapprovedunknownenzymeinhibitorDetails
Sitaxentanapproved, investigational, withdrawnunknownenzymeinhibitorDetails
Aminophenazoneapproved, withdrawnunknownenzymesubstrateDetails
ClozapineapprovednoenzymesubstrateinhibitorinducerDetails
Promazineapproved, vet_approvedunknownenzymesubstrateDetails
Carvedilolapproved, investigationalunknownenzymesubstrateDetails
Zafirlukastapproved, investigationalunknownenzymesubstrateinhibitorDetails
Diclofenacapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
Celecoxibapproved, investigationalunknownenzymesubstrateDetails
GlyburideapprovedunknownenzymesubstrateinhibitorDetails
SulfinpyrazoneapprovedunknownenzymesubstrateinducerDetails
SeratrodastexperimentalunknownenzymesubstrateinducerDetails
KetobemidoneinvestigationalunknownenzymesubstrateDetails
Clomipramineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
EstroneapprovednoenzymesubstrateDetails
ImipramineapprovedunknownenzymesubstrateDetails
AdinazolamexperimentalunknownenzymesubstrateDetails
Temazepamapproved, investigationalunknownenzymesubstrateDetails
VanoxerineinvestigationalunknownenzymesubstrateDetails
Cholecalciferolapproved, nutraceuticalunknownenzymesubstrateDetails
Oxymorphoneapproved, investigational, vet_approvedunknownenzymesubstrateDetails
OrphenadrineapprovedunknownenzymesubstrateinhibitorDetails
CabazitaxelapprovedunknownenzymesubstrateDetails
ResveratrolinvestigationalnoenzymeinhibitorDetails
Desvenlafaxineapproved, investigationalnoenzymesubstrateinhibitorDetails
ArtemetherapprovedunknownenzymesubstrateinducerDetails
LumefantrineapprovedunknownenzymesubstrateDetails
Acetazolamideapproved, vet_approvedunknownenzymeinhibitorDetails
Ambroxolapproved, investigationalunknownenzymesubstrateDetails
AminophyllineapprovedunknownenzymesubstrateDetails
Argatrobanapproved, investigationalunknownenzymesubstrateDetails
Arsenic trioxideapproved, investigationalunknownenzymeinhibitorDetails
AzithromycinapprovedunknownenzymesubstrateinhibitorDetails
Bezafibrateapproved, investigationalunknownenzymesubstrateDetails
Bifonazoleapproved, investigationalunknownenzymeinhibitorDetails
BrinzolamideapprovednoenzymesubstrateDetails
CaspofunginapprovedunknownenzymeinhibitorDetails
Chlorpromazineapproved, investigational, vet_approvedunknownenzymeinducerDetails
ChlorzoxazoneapprovedunknownenzymesubstrateinhibitorDetails
Clofazimineapproved, investigationalunknownenzymeinhibitorDetails
ClomethiazoleinvestigationalunknownenzymesubstrateDetails
Clotiazepamapproved, illicitunknownenzymesubstrateDetails
Cytarabineapproved, investigationalunknownenzymesubstrateDetails
DanazolapprovedunknownenzymeinhibitorDetails
DaunorubicinapprovedunknownenzymesubstrateinhibitorDetails
Dimethyl sulfoxideapproved, vet_approvedunknownenzymeinhibitorDetails
DisulfiramapprovedunknownenzymesubstrateDetails
Doxycyclineapproved, investigational, vet_approvedunknownenzymeinhibitorDetails
EconazoleapprovednoenzymeinhibitorDetails
Epinastineapproved, investigationalunknownenzymesubstrateDetails
Epinephrineapproved, vet_approvedunknownenzymeinhibitorDetails
Estramustineapproved, investigationalunknownenzymesubstrateDetails
EthanolapprovedunknownenzymesubstrateinhibitorinducerDetails
Ethylmorphineexperimental, illicitunknownenzymesubstrateDetails
Flucloxacillinapproved, investigationalunknownenzymesubstrateinducerDetails
Flunitrazepamapproved, illicitunknownenzymesubstrateDetails
Fulvestrantapproved, investigationalunknownenzymesubstrateDetails
HydralazineapprovednoenzymeinhibitorDetails
Imiquimodapproved, investigationalunknownenzymesubstrateDetails
Irbesartanapproved, investigationalnoenzymeinhibitorDetails
Ivermectinapproved, investigational, vet_approvednoenzymesubstrateDetails
QuinacrineinvestigationalunknownenzymesubstrateDetails
MequitazineexperimentalunknownenzymeinhibitorDetails
Metamizoleapproved, investigational, withdrawnunknownenzymeinducerDetails
Methaqualoneillicit, withdrawnunknownenzymesubstrateDetails
Methoxyfluraneapproved, investigational, vet_approved, withdrawnunknownenzymesubstrateDetails
MethyltestosteroneapprovedunknownenzymesubstrateDetails
Mexiletineapproved, investigationalunknownenzymesubstrateDetails
Mitoxantroneapproved, investigationalunknownenzymeinhibitorDetails
Morphineapproved, investigationalnoenzymesubstrateDetails
Naloxoneapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
Nicotinamideapproved, investigationalunknownenzymeinhibitorDetails
NicotineapprovedunknownenzymesubstrateDetails
NitrazepamapprovedunknownenzymesubstrateDetails
OlopatadineapprovednoenzymesubstrateDetails
AcetaminophenapprovedunknownenzymesubstrateinducerDetails
Perhexilineapproved, investigationalunknownenzymesubstrateDetails
PerphenazineapprovedunknownenzymesubstrateDetails
MeperidineapprovedunknownenzymesubstrateinducerDetails
PhenacetinwithdrawnunknownenzymesubstrateDetails
PhenelzineapprovedunknownenzymeinhibitorDetails
Phenylbutazoneapproved, vet_approvedunknownenzymeinducerDetails
Pilocarpineapproved, investigationalunknownenzymeinhibitorDetails
Prazepamapproved, illicitunknownenzymesubstrateDetails
Probenecidapproved, investigationalunknownenzymeinducerDetails
PropafenoneapprovedunknownenzymesubstrateDetails
Quazepamapproved, illicitnoenzymesubstrateDetails
Raloxifeneapproved, investigationalunknownenzymeinhibitorDetails
Ranitidineapproved, withdrawnunknownenzymeinhibitorDetails
Rifaximinapproved, investigationalunknownenzymesubstrateinducerDetails
RopivacaineapprovedunknownenzymesubstrateDetails
Rutinapproved, experimental, investigationalunknownenzymeinducerDetails
Albuterolapproved, vet_approvedunknownenzymeinhibitorDetails
Sevofluraneapproved, vet_approvedunknownenzymesubstrateDetails
Sulfadiazineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
SulfamethoxazoleapprovedunknownenzymesubstrateDetails
TasosartanexperimentalunknownenzymesubstrateDetails
MethimazoleapprovedunknownenzymeinhibitorDetails
Thiotepaapproved, investigationalunknownenzymesubstrateDetails
TioconazoleapprovedunknownenzymeinhibitorDetails
TopiramateapprovedunknownenzymeinducerDetails
TrimethadioneapprovedunknownenzymesubstrateDetails
TroleandomycinapprovedunknownenzymesubstrateinhibitorDetails
Valproic acidapproved, investigationalunknownenzymeinhibitorDetails
Yohimbineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
ZidovudineapprovedunknownenzymesubstrateDetails
ZomepiracwithdrawnunknownenzymesubstrateDetails
Cortisone acetateapproved, investigationalunknownenzymesubstrateinducerDetails
ParamethasoneexperimentalunknownenzymesubstrateinhibitorinducerDetails
KetazolamapprovedunknownenzymesubstrateinhibitorDetails
TofisopamexperimentalunknownenzymeinhibitorDetails
ParamethadioneapprovedunknownenzymesubstrateDetails
Tretinoinapproved, investigational, nutraceuticalunknownenzymesubstrateDetails
Ramelteonapproved, investigationalunknownenzymesubstrateDetails
IloperidoneapprovedunknownenzymesubstrateDetails
Acenocoumarolapproved, investigationalunknownenzymesubstrateDetails
VilazodoneapprovedunknownenzymesubstrateDetails
Diethylstilbestrolapproved, investigational, withdrawnunknownenzymesubstrateinhibitorDetails
ClonidineapprovedunknownenzymesubstrateDetails
EzetimibeapprovedunknownenzymeinhibitorDetails
Griseofulvinapproved, investigational, vet_approvedunknownenzymeinducerDetails
IndapamideapprovedunknownenzymesubstrateDetails
Telaprevirapproved, withdrawnunknownenzymesubstrateinhibitorDetails
IvacaftorapprovednoenzymesubstrateinhibitorDetails
CasopitantinvestigationalunknowntargetDetails
BanoxantroneinvestigationalunknownenzymesubstrateDetails
IndacaterolapprovedunknownenzymesubstrateDetails
TicagrelorapprovedunknownenzymesubstrateinhibitorDetails
CapsaicinapprovedunknownenzymeinhibitorDetails
Noscapineapproved, investigationalunknownenzymeinhibitorDetails
CefradineapprovedunknownenzymeinducerDetails
Chenodeoxycholic acidapprovedunknownenzymesubstrateDetails
Chlorphenesinapproved, experimentalunknownenzymeinducerDetails
Clevidipineapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
DalfopristinapprovedunknownenzymeinhibitorDetails
Deferasiroxapproved, investigationalunknownenzymeinducerDetails
Dicloxacillinapproved, investigational, vet_approvedunknownenzymeinducerDetails
IndisulaminvestigationalunknownenzymeinhibitorDetails
Orlistatapproved, investigationalunknownenzymeinducerDetails
OxiconazoleapprovedunknownenzymeinducerDetails
PegvisomantapprovedunknownenzymeinducerDetails
PinacidilapprovedunknownenzymesubstrateDetails
QuinupristinapprovedunknownenzymeinhibitorDetails
Pimecrolimusapproved, investigationalunknownenzymesubstrateDetails
AldesleukinapprovedunknownenzymeinhibitorDetails
ApixabanapprovednoenzymesubstrateDetails
Lomitapideapproved, investigationalnoenzymesubstrateDetails
Vismodegibapproved, investigationalnoenzymesubstrateDetails
Triamcinoloneapproved, vet_approvedunknownenzymesubstrateinducerDetails
RilpivirineapprovednoenzymesubstrateinhibitorinducerDetails
PrasugrelapprovednoenzymesubstrateDetails
AsenapineapprovedunknownenzymesubstrateDetails
Nitric OxideapprovedunknownenzymeinhibitorDetails
UlipristalapprovednoenzymesubstrateDetails
Lurasidoneapproved, investigationalunknownenzymesubstrateDetails
Brentuximab vedotinapproved, investigationalnoenzymesubstrateinhibitorDetails
Lorcaserinapproved, withdrawnnoenzymesubstrateDetails
VandetanibapprovedunknownenzymesubstrateDetails
Boceprevirapproved, withdrawnunknownenzymesubstrateinhibitorDetails
Cabozantinibapproved, investigationalnoenzymesubstrateDetails
RuxolitinibapprovedunknownenzymesubstrateDetails
AbirateroneapprovedunknownenzymesubstrateinhibitorDetails
VemurafenibapprovedunknownenzymesubstrateinducerDetails
LinagliptinapprovedunknownenzymesubstrateinhibitorDetails
PerampanelapprovednoenzymesubstrateinducerDetails
Crizotinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Axitinibapproved, investigationalnoenzymesubstrateDetails
MirabegronapprovednoenzymesubstrateDetails
AvanafilapprovedunknownenzymesubstrateDetails
RegorafenibapprovedunknownenzymesubstrateinhibitorDetails
EnzalutamideapprovednoenzymesubstrateinducerDetails
Tofacitinibapproved, investigationalnoenzymesubstrateDetails
BosutinibapprovednoenzymesubstrateinhibitorDetails
Ponatinibapproved, investigationalunknownenzymesubstrateDetails
BedaquilineapprovednoenzymesubstrateDetails
RufinamideapprovedunknownenzymeinducerDetails
Fluticasone furoateapprovednoenzymesubstrateinhibitorinducerDetails
CanagliflozinapprovedunknownenzymesubstrateDetails
AlogliptinapprovedunknownenzymesubstrateDetails
Ospemifeneapproved, investigationalunknownenzymesubstrateDetails
PomalidomideapprovedunknownenzymesubstrateDetails
TrametinibapprovedunknownenzymesubstrateinducerDetails
Dabrafenibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Trastuzumab emtansineapproved, investigationalunknownenzymesubstrateDetails
Taurochenodeoxycholic acidexperimentalunknownenzymesubstrateDetails
Doxepinapproved, investigationalnoenzymesubstrateDetails
Mycophenolate mofetilapproved, investigationalunknownenzymesubstrateDetails
Levomilnacipranapproved, investigationalunknownenzymesubstrateDetails
MacitentanapprovednoenzymesubstrateDetails
LuliconazoleapprovednoenzymeinhibitorDetails
DapagliflozinapprovednoenzymesubstrateDetails
Eliglustatapproved, investigationalnoenzymesubstrateDetails
Apremilastapproved, investigationalnoenzymesubstrateDetails
NaloxegolapprovedunknownenzymesubstrateDetails
IbrutinibapprovedunknownenzymesubstrateDetails
Isoniazidapproved, investigationalunknowntargetDetails
OlaparibapprovedunknownenzymesubstrateinhibitorDetails
Lenvatinibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Palbociclibapproved, investigationalnoenzymesubstrateinhibitorDetails
IdelalisibapprovednoenzymesubstrateinhibitorinducerDetails
Vortioxetineapproved, investigationalnoenzymesubstrateDetails
VilanterolapprovednoenzymesubstrateDetails
IvabradineapprovednoenzymesubstrateDetails
Aliskirenapproved, investigationalnoenzymesubstrateDetails
ElvitegravirapprovednoenzymesubstrateinhibitorDetails
Cariprazineapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
ParecoxibapprovedunknownenzymesubstrateDetails
Brexpiprazoleapproved, investigationalnoenzymesubstrateDetails
Rolapitantapproved, investigationalnoenzymesubstrateDetails
Flibanserinapproved, investigationalnoenzymesubstrateDetails
Daclatasvirapproved, investigationalunknownenzymesubstrateDetails
Sonidegibapproved, investigationalunknownenzymesubstrateDetails
Isavuconazoniumapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Panobinostatapproved, investigationalunknownenzymesubstrateDetails
Cobimetinibapproved, investigationalnoenzymesubstrateinhibitorDetails
Ixazomibapproved, investigationalunknownenzymesubstrateDetails
OsimertinibapprovednoenzymesubstrateinhibitorinducerDetails
SelexipagapprovednoenzymesubstrateDetails
Eslicarbazepine acetateapprovednoenzymeinducerDetails
Hydroxyprogesterone caproateapproved, investigationalunknownenzymesubstrateDetails
RiociguatapprovedunknownenzymesubstrateDetails
DasabuvirapprovednoenzymesubstrateDetails
Paritaprevirapproved, investigationalnoenzymesubstrateDetails
Synthetic Conjugated Estrogens, AapprovednoenzymesubstrateDetails
Synthetic Conjugated Estrogens, BapprovednoenzymesubstrateDetails
NorgestrelapprovedunknownenzymesubstrateDetails
Venetoclaxapproved, investigationalnoenzymesubstrateinhibitorDetails
LumacaftorapprovednoenzymeinducerDetails
St. John's Wortapproved, investigational, nutraceuticalunknownenzymesubstrateinduceractivatorDetails
Esterified estrogensapprovedunknownenzymesubstrateDetails
Norgestimateapproved, investigationalunknownenzymesubstrateinducerDetails
Oritavancinapproved, investigationalunknownenzymeinhibitorinducerDetails
FosaprepitantapprovedunknownenzymesubstrateinhibitorinducerDetails
MitotaneapprovedunknownenzymeinducerDetails
Glycerol phenylbutyrateapprovedunknownenzymeinducerDetails
Netupitantapproved, investigationalnoenzymesubstrateinhibitorDetails
Rucaparibapproved, investigationalnoenzymesubstrateinhibitorDetails
Deflazacortapproved, investigationalnoenzymesubstrateinducerDetails
Icotinibexperimental, investigationalunknownenzymesubstrateDetails
Safinamideapproved, investigationalunknownenzymesubstrateDetails
Deutetrabenazineapproved, investigationalnoenzymesubstrateDetails
Dexchlorpheniramine maleateapprovedunknownenzymesubstrateDetails
Velpatasvirapproved, investigationalnoenzymesubstrateDetails
Brivaracetamapproved, investigationalnoenzymesubstrateDetails
Valbenazineapproved, investigationalnoenzymesubstrateDetails
OdanacatibinvestigationalnoenzymesubstrateDetails
Dexlansoprazoleapproved, investigationalunknownenzymesubstrateDetails
SimeprevirapprovedunknownenzymesubstrateinhibitorDetails
GrazoprevirapprovednoenzymesubstrateinhibitorDetails
Delafloxacinapproved, investigationalunknownenzymeinducerDetails
TopiroxostatexperimentalunknownenzymeinhibitorDetails
PerospironeexperimentalunknownenzymesubstrateDetails
StiripentolapprovedunknownenzymesubstrateinhibitorinducerDetails
EtizolamexperimentalunknownenzymesubstrateDetails
RupatadineapprovednoenzymesubstrateDetails
ImidafenacininvestigationalnoenzymesubstrateDetails
Glutathioneapproved, investigational, nutraceuticalunknowntargetDetails
Manidipineapproved, investigationalunknownenzymesubstrateinhibitorDetails
DienogestapprovedunknownenzymesubstrateDetails
Neratinibapproved, investigationalunknownenzymesubstrateDetails
Voxilaprevirapproved, investigationalnoenzymesubstrateDetails
Enasidenibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Oxymetholoneapproved, illicitunknownenzymeinhibitorDetails
Ritonavirapproved, investigationalunknownenzymesubstrateinhibitorDetails
Midostaurinapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
ElbasvirapprovedunknownenzymesubstrateDetails
Copanlisibapproved, investigationalnoenzymesubstrateDetails
Sarilumabapproved, investigationalnoenzymeinhibitorinducerDetails
Abemaciclibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Brigatinibapproved, investigationalnoenzymesubstrateDetails
Baricitinibapproved, investigationalunknownenzymesubstrateDetails
Macimorelinapproved, investigationalunknownenzymesubstrateDetails
BlonanserininvestigationalnoenzymesubstrateDetails
Lacidipineapproved, investigationalunknownenzymesubstrateDetails
Cannabidiolapproved, investigationalunknownenzymesubstrateinhibitorDetails
Testosterone cypionateapprovedunknownenzymesubstrateinhibitorinducerDetails
Testosterone enanthateapprovedunknownenzymesubstrateinhibitorinducerDetails
Testosterone undecanoateapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Estradiol acetateapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Estradiol benzoateapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Estradiol cypionateapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Estradiol valerateapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Piperaquineapproved, experimental, investigationalunknownenzymesubstrateinhibitorDetails
Testosterone propionateapproved, investigational, vet_approved, withdrawnnoenzymesubstrateDetails
LorpiprazoleapprovednoenzymesubstrateDetails
Bictegravirapproved, investigationalunknownenzymesubstrateDetails
Apalutamideapproved, investigationalnoenzymesubstrateinducerDetails
Zotepineapproved, investigational, withdrawnnoenzymesubstrateDetails
AzelnidipineinvestigationalunknownenzymesubstrateDetails
BenidipineexperimentalnoenzymesubstrateinhibitorDetails
EfonidipineexperimentalunknownenzymesubstrateinhibitorDetails
Pitolisantapproved, investigationalunknownenzymesubstrateinducerDetails
Isavuconazoleapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Levamlodipineapproved, investigationalunknownenzymesubstrateDetails
Tezacaftorapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Opiumapproved, illicitnoenzymesubstrateDetails
Tocopherolapproved, investigationalnoenzymesubstrateDetails
alpha-Tocopherol acetateapprovednoenzymesubstrateDetails
Asunaprevirapproved, investigational, withdrawnnoenzymesubstrateinducerDetails
Black cohoshexperimentalnoenzymeinhibitorDetails
Propiverineapproved, investigationalnoenzymesubstrateDetails
NabiximolsinvestigationalunknownenzymesubstrateDetails
Medical Cannabisexperimental, investigationalunknownenzymesubstrateinhibitorDetails
Vinflunineapproved, investigationalnoenzymesubstrateDetails
TocofersolanapprovednoenzymesubstrateDetails
Delamanidapproved, investigationalnoenzymesubstrateDetails
Bioallethrinapproved, experimentalnoenzymesubstrateDetails
FosnetupitantapprovedunknownenzymesubstrateinhibitorDetails
Fostamatinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Ergoloid mesylateapprovednoenzymesubstrateDetails
Dihydro-alpha-ergocryptineapprovednoenzymesubstrateDetails
Ipecacapproved, withdrawnnoenzymesubstrateDetails
Peppermint oilapproved, investigationalunknownenzymeinhibitorDetails
MidecamycinexperimentalnoenzymesubstrateinhibitorDetails
Oxetacaineapproved, investigationalnoenzymeinhibitorDetails
Curcuminapproved, investigationalunknownenzymeinhibitorDetails
DanoprevirinvestigationalnoenzymeinhibitorDetails
TianeptineinvestigationalnoenzymesubstrateDetails
MestranolapprovednoenzymesubstrateDetails
Lysergic acid diethylamideillicit, investigational, withdrawnnoenzymesubstrateDetails
MethysergideapprovednoenzymesubstrateDetails
TergurideexperimentalnoenzymesubstrateDetails
Aripiprazole lauroxilapproved, investigationalunknownenzymesubstrateDetails
Encorafenibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Hydrocortisone aceponateexperimental, vet_approvedunknownenzymesubstrateinducerDetails
Hydrocortisone acetateapproved, vet_approvedunknownenzymesubstrateinducerDetails
Hydrocortisone butyrateapproved, vet_approvedunknownenzymesubstrateinducerDetails
Hydrocortisone cypionateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone phosphateapproved, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone probutateapproved, vet_approvedunknownenzymesubstrateinducerDetails
Hydrocortisone valerateapproved, vet_approvedunknownenzymesubstrateinducerDetails
Ivosidenibapproved, investigationalunknownenzymesubstrateinducerDetails
3,5-diiodothyropropionic acidinvestigationalnoenzymesubstrateDetails
5-androstenedioneexperimental, illicitnoenzymesubstrateDetails
AlclometasoneapprovednoenzymesubstrateDetails
Aldosteroneexperimental, investigationalnoenzymesubstrateDetails
AmcinonideapprovednoenzymesubstrateinducerDetails
Androstenedioneexperimental, illicitnoenzymesubstrateDetails
Beclomethasone dipropionateapproved, investigationalnoenzymesubstrateinducerDetails
Clobetasolapproved, experimental, investigationalnoenzymesubstrateinducerDetails
Clobetasol propionateapprovednoenzymesubstrateinducerDetails
ClobetasoneapprovednoenzymesubstrateDetails
CorticosteroneexperimentalnoenzymesubstrateDetails
Corticotropinapproved, investigational, vet_approvednoenzymesubstrateinducerDetails
Cyproterone acetateapproved, investigationalnoenzymesubstrateinhibitorDetails
NomegestrolapprovednoenzymesubstrateDetails
Nomegestrol acetateapproved, investigationalnoenzymesubstrateDetails
DesogestrelapprovednoenzymesubstrateDetails
Desonideapproved, investigationalnoenzymesubstrateinducerDetails
Desoxycorticosterone acetateapprovednoenzymesubstrateDetails
Desoxycorticosterone pivalateexperimental, vet_approvednoenzymesubstrateDetails
Dexamethasone isonicotinatevet_approvednoenzymesubstrateinhibitorinducerDetails
Difluocortoloneapproved, investigational, withdrawnnoenzymesubstrateinducerDetails
DifluprednateapprovednoenzymesubstrateDetails
Dydrogesteroneapproved, investigational, withdrawnnoenzymesubstrateDetails
EquileninexperimentalnoenzymesubstrateDetails
EquilinexperimentalnoenzymesubstrateDetails
EtynodiolexperimentalnoenzymesubstrateDetails
Ethynodiol diacetateapprovednoenzymesubstrateDetails
Fludrocortisoneapproved, investigationalunknownenzymesubstrateDetails
Flumethasoneapproved, vet_approvednoenzymesubstrateDetails
Fluocinolone acetonideapproved, investigational, vet_approvednoenzymesubstrateinducerDetails
Fluocinonideapproved, investigationalnoenzymesubstrateinducerDetails
Fluocortoloneapproved, withdrawnnoenzymesubstrateinducerDetails
FluprednideneexperimentalnoenzymesubstrateinducerDetails
FluprednisoloneapprovednoenzymesubstrateDetails
FlurandrenolideapprovednoenzymesubstrateDetails
Fluticasoneapproved, experimentalnoenzymesubstrateinhibitorinducerDetails
Formestaneapproved, investigational, withdrawnnoenzymeinducerDetails
GestodeneinvestigationalnoenzymesubstrateinhibitorDetails
GestrinoneapprovednoenzymesubstrateDetails
Halcinonideapproved, investigational, withdrawnnoenzymesubstrateDetails
HE3286investigationalnoenzymesubstrateDetails
Hydrocortisone succinateapprovedunknownenzymesubstrateinducerDetails
HydroxyprogesteroneexperimentalnoenzymesubstrateDetails
LiotrixapprovednoenzymesubstrateDetails
Loteprednol etabonateapprovedunknownenzymesubstrateDetails
Lynestrenolapproved, investigationalnoenzymesubstrateDetails
Medrogestoneapproved, withdrawnnoenzymesubstrateDetails
MedrysoneapprovednoenzymesubstrateinducerDetails
Megestrol acetateapproved, investigational, vet_approvednoenzymesubstrateDetails
Melengestrolvet_approvednoenzymesubstrateDetails
Meprednisoneapproved, investigationalnoenzymesubstrateinducerDetails
MometasoneexperimentalnoenzymesubstrateinducerDetails
Mometasone furoateapproved, investigational, vet_approvednoenzymesubstrateinducerDetails
Norelgestrominapproved, investigationalnoenzymesubstrateDetails
NorethynodrelapprovednoenzymesubstrateDetails
Prednicarbateapproved, investigationalnoenzymesubstrateDetails
PrednylideneexperimentalnoenzymesubstrateinducerDetails
Pregnenoloneapproved, experimentalnoenzymesubstrateDetails
PromegestoneexperimentalnoenzymesubstrateDetails
RimexoloneapprovednoenzymesubstrateinducerDetails
AtovaquoneapprovednoenzymesubstrateDetails
Rifamycinapproved, investigationalnoenzymeinhibitorinducerDetails
ChlormadinoneexperimentalnoenzymesubstrateDetails
DemegestoneexperimentalnoenzymesubstrateDetails
QuingestanolexperimentalnoenzymesubstrateDetails
(S)-Warfarinexperimental, investigationalnoenzymesubstrateDetails
DiphenadioneexperimentalnoenzymesubstrateDetails
Ethyl biscoumacetatewithdrawnunknownenzymesubstrateDetails
BarbitalillicitnoenzymeinducerDetails
Thiamylalapproved, vet_approvednoenzymesubstrateinducerDetails
AranidipineexperimentalnoenzymesubstrateDetails
BarnidipineexperimentalnoenzymesubstrateinhibitorDetails
BencyclaneexperimentalnoenzymesubstrateDetails
Bepridilapproved, withdrawnnoenzymesubstrateDetails
AgmatineexperimentalnoenzymesubstrateDetails
CarboxyamidotriazoleinvestigationalnoenzymesubstrateDetails
CaroverineexperimentalnoenzymesubstrateDetails
CilnidipineinvestigationalnoenzymesubstrateDetails
Cinnarizineapproved, investigationalnoenzymesubstrateDetails
CyclandelateapprovednoenzymesubstrateDetails
DarodipineexperimentalnoenzymesubstrateDetails
DexniguldipineexperimentalnoenzymesubstrateDetails
DexverapamilexperimentalnoenzymesubstrateDetails
DotarizineinvestigationalnoenzymesubstrateDetails
EmopamilexperimentalnoenzymesubstrateDetails
EperisoneinvestigationalnoenzymesubstrateDetails
FendilinewithdrawnnoenzymesubstrateDetails
Fish oilapproved, nutraceuticalnoenzymesubstrateDetails
FlunarizineapprovednoenzymesubstrateDetails
Fluspirileneapproved, investigationalnoenzymesubstrateDetails
GallopamilinvestigationalnoenzymesubstrateDetails
Lidoflazineapproved, experimentalnoenzymesubstrateDetails
LomerizineexperimentalnoenzymesubstrateDetails
LevomentholapprovednoenzymesubstrateDetails
NaftopidilinvestigationalnoenzymesubstrateDetails
NiguldipineexperimentalnoenzymesubstrateDetails
NiludipineexperimentalnoenzymesubstrateDetails
Nimesulideapproved, investigational, withdrawnnoenzymesubstrateDetails
NylidrinapprovednoenzymesubstrateDetails
Otiloniumexperimental, investigationalnoenzymesubstrateDetails
PenfluridolexperimentalnoenzymesubstrateDetails
PinaveriumapprovednoenzymesubstrateDetails
Prenylamineapproved, withdrawnnoenzymesubstrateDetails
TerodilineexperimentalnoenzymesubstrateDetails
TetrahydropalmatineinvestigationalnoenzymesubstrateDetails
TetrandrineexperimentalnoenzymesubstrateDetails
Tolfenamic acidapproved, investigationalnoenzymesubstrateDetails
TranilastinvestigationalnoenzymesubstrateDetails
TrimebutineapprovednoenzymesubstrateDetails
SeletracetaminvestigationalnoenzymesubstrateDetails
VinpocetineinvestigationalnoenzymesubstrateDetails
WIN 55212-2experimentalnoenzymesubstrateinhibitorDetails
6-Deoxyerythronolide BexperimentalnoenzymeinhibitorDetails
AVE9633investigationalnoenzymeinhibitorDetails
Brefeldin AexperimentalnoenzymeinhibitorDetails
Bryostatin 1investigationalnoenzymeinhibitorDetails
Candicidinapproved, withdrawnnoenzymeinhibitorDetails
Carbomycinvet_approvednoenzymeinhibitorDetails
CethromycininvestigationalnoenzymesubstrateinhibitorDetails
Coltuximab ravtansineinvestigationalnoenzymeinhibitorDetails
DirithromycinexperimentalnoenzymeinhibitorDetails
Doramectinvet_approvednoenzymeinhibitorDetails
EpofolateinvestigationalnoenzymeinhibitorDetails
Epothilone DinvestigationalnoenzymeinhibitorDetails
Eprinomectinvet_approvednoenzymeinhibitorDetails
FlurithromycinexperimentalnoenzymeinhibitorDetails
GPI-1485investigationalnoenzymeinhibitorDetails
KitasamycinexperimentalnoenzymeinhibitorDetails
KOS-1584investigationalnoenzymeinhibitorDetails
Lorvotuzumab mertansineinvestigationalnoenzymeinhibitorDetails
MiocamycinapprovednoenzymeinhibitorDetails
Mirvetuximab soravtansineapproved, investigationalnoenzymesubstrateinhibitorDetails
MitemcinalinvestigationalnoenzymeinhibitorDetails
Oleandomycinvet_approvednoenzymeinhibitorDetails
Patupiloneexperimental, investigationalnoenzymeinhibitorDetails
RidaforolimusinvestigationalnoenzymeinhibitorDetails
RokitamycinexperimentalnoenzymeinhibitorDetails
SagopiloneinvestigationalnoenzymeinhibitorDetails
Selamectinvet_approvednoenzymeinhibitorDetails
SolithromycininvestigationalnoenzymeinhibitorDetails
Tildipirosinvet_approvednoenzymeinhibitorDetails
GemfibrozilapprovedunknownenzymesubstrateDetails
LanreotideapprovednoenzymeinhibitorDetails
Octreotideapproved, investigationalnoenzymeinhibitorDetails
PasireotideapprovednoenzymeinhibitorDetails
Somatostatinapproved, investigationalnoenzymeinhibitorDetails
Vapreotideexperimental, investigationalnoenzymeinhibitorDetails
BalaglitazoneinvestigationalnoenzymesubstrateDetails
CiglitazoneexperimentalnoenzymesubstrateDetails
LobeglitazoneexperimentalnoenzymesubstrateDetails
NetoglitazoneexperimentalnoenzymesubstrateDetails
Rivoglitazoneexperimental, investigationalnoenzymesubstrateDetails
Rosiglitazoneapproved, investigationalnoenzymesubstrateinducerDetails
CeritinibapprovednoenzymesubstrateinhibitorDetails
LestaurtinibinvestigationalnoenzymeinhibitorDetails
SaracatinibinvestigationalnoenzymeinhibitorDetails
Acalabrutinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
PaliperidoneapprovedunknownenzymesubstrateDetails
GenisteininvestigationalunknownenzymeinducerDetails
DovitinibinvestigationalunknownenzymeinhibitorDetails
(R)-warfarinexperimentalunknownenzymesubstrateDetails
6-O-benzylguanineinvestigationalnoenzymesubstrateDetails
Segesterone acetateapproved, experimental, investigationalunknownenzymesubstrateDetails
MethotrexateapprovednoenzymesubstrateDetails
DapoxetineinvestigationalnoenzymesubstrateinhibitorDetails
Indalpineinvestigational, withdrawnnoenzymesubstrateinhibitorDetails
Paroxetineapproved, investigationalnoenzymesubstrateinhibitorDetails
Zimelidineapproved, withdrawnnoenzymeinhibitorDetails
Milnacipranapproved, investigationalnoenzymesubstrateinhibitorDetails
Fusidic acidapproved, investigationalunknownenzymesubstrateinhibitorDetails
Ribociclibapproved, investigationalnoenzymesubstrateinhibitorDetails
NintedanibapprovednoenzymesubstrateDetails
Fluprednidene acetateexperimentalnoenzymeinducerDetails
Fluprednisolone acetateexperimentalnoenzymesubstrateDetails
RoflumilastapprovednoenzymesubstrateDetails
Suvorexantapproved, investigationalnoenzymesubstrateDetails
Tasimelteonapproved, investigationalnoenzymesubstrateDetails
VorapaxarapprovednoenzymesubstrateDetails
Zuclopenthixolapproved, investigationalnoenzymesubstrateDetails
DihydroergocryptineexperimentalnoenzymesubstrateDetails
DihydroergocornineapprovednoenzymesubstrateDetails
Dihydroergocristineapproved, experimentalnoenzymesubstrateDetails
LacosamideapprovednoenzymesubstrateDetails
Eravacyclineapproved, investigationalunknownenzymesubstrateDetails
RemacemideinvestigationalnoenzymeinhibitorDetails
FidaxomicinapprovednoenzymeinhibitorDetails
Ebastineapproved, investigationalnoenzymesubstrateDetails
Siltuximabapproved, investigationalnoenzymeinducerDetails
TocilizumabapprovednoenzymeinducerDetails
Doravirineapproved, investigationalunknownenzymesubstrateDetails
Duvelisibapproved, investigationalnoenzymesubstrateDetails
Baloxavir marboxilapproved, investigationalnoenzymesubstrateinhibitorDetails
9-aminocamptothecininvestigationalnoenzymesubstrateDetails
Methylprednisoneapproved, investigationalnoenzymesubstrateDetails
Nebivololapproved, investigationalunknownenzymesubstrateDetails
Dacomitinibapproved, investigationalnoenzymesubstrateDetails
Gilteritinibapproved, investigationalnoenzymesubstrateDetails
Larotrectinibapproved, investigationalnoenzymesubstrateDetails
1,2-Benzodiazepineapproved, investigationalunknownenzymesubstrateDetails
Brotizolaminvestigational, withdrawnunknownenzymesubstrateDetails
Vitamin Dapproved, nutraceutical, vet_approvednoenzymesubstrateDetails
Aprobarbitalexperimental, illicitunknownenzymeinducerDetails
DoxazosinapprovednoenzymesubstrateDetails
SN-38investigationalunknownenzymesubstrateinhibitorDetails
PrucaloprideapprovednoenzymesubstrateDetails
Glasdegibapproved, investigationalnoenzymesubstrateDetails
PiperineinvestigationalunknownenzymeinhibitorDetails
Phentermineapproved, illicitnoenzymesubstrateDetails
Triclabendazoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
Metoprololapproved, investigationalnoenzymesubstrateDetails
Esketamineapproved, investigationalunknownenzymesubstrateinducerDetails
Vitamin Eapproved, nutraceutical, vet_approvedunknownenzymesubstrateinducerDetails
Siponimodapproved, investigationalunknownenzymesubstrateDetails
Erdafitinibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Tenofovir alafenamideapprovednoenzymesubstrateDetails
IsotretinoinapprovedunknownenzymesubstrateDetails
Alpelisibapproved, investigationalunknownenzymesubstrateDetails
Polatuzumab vedotinapproved, investigationalnoenzymesubstrateDetails
Bimatoprostapproved, investigationalunknownenzymesubstrateDetails
Selinexorapproved, investigationalunknownenzymesubstrateDetails
Betamethasone phosphateapproved, vet_approvedunknownenzymesubstrateinducerDetails
Clocortolone acetateexperimentalunknownenzymeinducerDetails
CloprednolexperimentalunknownenzymeinducerDetails
CortisoneexperimentalunknownenzymeinducerDetails
CortivazolinvestigationalunknownenzymeinducerDetails
HalometasoneexperimentalunknownenzymeinducerDetails
Melengestrol acetateexperimentalunknownenzymeinducerDetails
Methylprednisolone hemisuccinateapprovedunknownenzymeinducerDetails
Prednisolone hemisuccinateexperimentalunknownenzymeinducerDetails
Prednisolone phosphateapproved, vet_approvedunknownenzymesubstrateinducerDetails
Prednisone acetateapproved, experimental, investigationalunknownenzymeinducerDetails
DitiocarbexperimentalunknownenzymeinhibitorDetails
SeproxetineinvestigationalunknownenzymeinhibitorDetails
Niacinapproved, investigational, nutraceuticalunknownenzymeinhibitorDetails
LevocetirizineapprovedunknownenzymesubstrateDetails
ButyrfentanylillicitunknownenzymesubstrateDetails
Pexidartinibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Dihydrocodeineapproved, illicitunknownenzymesubstrateDetails
PretomanidapprovedunknownenzymesubstrateDetails
DrospirenoneapprovedunknownenzymesubstrateDetails
HydroxychloroquineapprovedunknownenzymesubstrateDetails
Entrectinibapproved, investigationalunknownenzymesubstrateDetails
Fedratinibapproved, investigationalunknownenzymesubstrateDetails
Lefamulinapproved, investigationalunknownenzymesubstrateDetails
Istradefyllineapproved, investigationalunknownenzymesubstrateDetails
FosamprenavirapprovedunknownenzymesubstrateinhibitorDetails
IbuprofenapprovednoenzymesubstrateDetails
MexazolamexperimentalunknownenzymesubstrateDetails
Olanzapineapproved, investigationalunknownenzymeinhibitorDetails
PropacetamolexperimentalunknownenzymesubstrateinducerDetails
Metoclopramideapproved, investigationalunknownenzymesubstrateDetails
Tenapanorapproved, investigationalunknownenzymesubstrateDetails
Curcumin sulfateexperimentalunknownenzymeinhibitorDetails
Edetate disodium anhydrousapproved, vet_approvedunknownenzymeinhibitorDetails
Anastrozoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
EslicarbazepineapprovedunknownenzymeinducerDetails
Trifaroteneapproved, investigationalunknownenzymesubstrateDetails
Elexacaftorapproved, investigationalnoenzymesubstrateinhibitorDetails
Prednisolone acetateapproved, vet_approvedunknownenzymesubstrateinducerDetails
HydroxyzineapprovednoenzymesubstrateDetails
Echinaceaapproved, experimentalunknownenzymeinducerDetails
Lesinuradapproved, investigationalunknownenzymeinducerDetails
Zanubrutinibapproved, investigationalnoenzymesubstrateDetails
Ginkgo bilobaapproved, investigational, nutraceuticalunknownenzymeinhibitorinducerDetails
Glecaprevirapproved, investigationalunknownenzymeinhibitorDetails
Voxelotorapproved, investigationalunknownenzymesubstrateDetails
NorethisteroneapprovedunknownenzymesubstrateDetails
Cenobamateapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Enfortumab vedotinapproved, investigationalunknownenzymesubstrateDetails
Trastuzumab deruxtecanapproved, investigationalunknownenzymesubstrateDetails
Lemborexantapproved, investigationalunknownenzymesubstrateDetails
Darolutamideapproved, investigationalunknownenzymesubstrateDetails
Lumateperoneapproved, investigationalnoenzymesubstrateDetails
Upadacitinibapproved, investigationalnoenzymesubstrateDetails
Ubrogepantapproved, investigationalunknownenzymesubstrateDetails
Avapritinibapproved, investigationalunknownenzymesubstrateDetails
Tazemetostatapproved, investigationalunknownenzymesubstrateDetails
Rimegepantapproved, investigationalnoenzymesubstrateinhibitorDetails
UmifenovirinvestigationalunknownenzymesubstrateDetails
Osilodrostatapproved, investigationalunknownenzymesubstrateinhibitorDetails
Norethindrone enanthateexperimentalunknownenzymesubstrateDetails
Methylene blueapproved, investigationalunknownenzymeinhibitorDetails
Ozanimodapproved, investigationalunknownenzymesubstrateDetails
Edetate calcium disodium anhydrousapprovedunknownenzymeinhibitorDetails
Selumetinibapproved, investigationalnoenzymesubstrateDetails
Pemigatinibapproved, investigationalnoenzymesubstrateDetails
Remdesivirapproved, investigationalunknownenzymesubstrateinhibitorDetails
Capmatinibapproved, investigationalunknownenzymesubstrateDetails
Selpercatinibapproved, investigationalunknownenzymesubstrateDetails
RipretinibapprovedunknownenzymesubstrateDetails
Apomorphineapproved, investigationalunknownenzymeDetails
Lurbinectedinapproved, investigationalunknownenzymesubstrateDetails
Dexamethasone acetateapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorinducerDetails
Fenfluramineapproved, illicit, investigational, withdrawnunknownenzymesubstrateDetails
Belinostatapproved, investigationalunknownenzymesubstrateDetails
Fostemsavirapproved, investigationalunknownenzymesubstrateDetails
Abametapirapproved, investigationalnoenzymeinhibitorDetails
Risdiplamapproved, investigationalunknownenzymesubstrateDetails
Oliceridineapproved, investigationalnoenzymesubstrateDetails
Clascoteroneapproved, investigationalnoenzymeinhibitorDetails
Pralsetinibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Lonafarnibapproved, investigationalunknownenzymesubstrateinhibitorDetails
BerotralstatapprovednoenzymeinhibitorDetails
Tirbanibulinapproved, investigationalnoenzymesubstrateinhibitorDetails
Vibegronapproved, investigationalnoenzymesubstrateDetails
Chlordiazepoxideapproved, illicit, investigationalunknownenzymesubstrateDetails
Tranylcypromineapproved, investigationalunknownenzymeinhibitorDetails
Menadioneapproved, nutraceuticalunknownenzymeinhibitorDetails
Levoketoconazoleapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
DuloxetineapprovedunknownenzymeinhibitorDetails
Voclosporinapproved, investigationalunknownenzymesubstrateinhibitorDetails
Tepotinibapproved, investigationalnoenzymesubstrateinhibitorDetails
Scopolamineapproved, investigationalnoenzymesubstrateDetails
EthambutolapprovedunknownenzymeinhibitorDetails
Umbralisibapproved, investigational, withdrawnunknownenzymesubstrateDetails
Casimersenapproved, investigationalnoenzymeinhibitorDetails
Pyridostigmineapproved, investigationalnoenzymeinducerDetails
Tivozanibapproved, investigationalunknownenzymesubstrateDetails
Ponesimodapproved, investigationalunknownenzymesubstrateDetails
Diosminapproved, investigationalunknownenzymeinhibitorDetails
Pimavanserinapproved, investigationalunknownenzymesubstrateDetails
Glycopyrroniumapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estetrolapproved, investigationalunknownenzymesubstrateDetails
Loncastuximab tesirineapproved, investigationalunknownenzymeDetails
Infigratinibapproved, investigationalnoenzymesubstrateDetails
Ibrexafungerpapproved, investigationalunknownenzymesubstrateinhibitorDetails
Samidorphanapproved, investigationalnoenzymesubstrateDetails
Finerenoneapproved, investigationalunknownenzymesubstrateDetails
Belumosudilapproved, investigationalnoenzymesubstrateDetails
Lorlatinibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Belzutifanapproved, investigationalnoenzymesubstrateDetails
Fexinidazoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
Mobocertinibapproved, investigationalunknownenzymesubstrateDetails
Tisotumab vedotinapprovednoenzymesubstrateDetails
Atogepantapproved, investigationalnoenzymesubstrateDetails
Maralixibatapproved, investigationalnoenzymeinhibitorDetails
Avacopanapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Asciminibapproved, investigationalnoenzymesubstrateinhibitorDetails
Maribavirapproved, investigationalnoenzymesubstrateDetails
Nirmatrelvirapproved, investigationalnoenzymesubstrateinhibitorDetails
DaridorexantapprovednoenzymesubstrateDetails
Sotagliflozinapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Abrocitinibapproved, investigationalnoenzymesubstrateDetails
Palovaroteneapproved, investigationalnoenzymesubstrateinducerDetails
Mitapivatapproved, investigationalnoenzymesubstrateinducerDetails
SecnidazoleapprovedunknownenzymesubstrateinhibitorDetails
Cannabinolexperimental, investigationalunknownenzymesubstrateinhibitorDetails
Nabiloneapproved, investigationalunknownenzymesubstrateinhibitorDetails
Nalmefeneapproved, investigational, withdrawnnoenzymesubstrateDetails
Pacritinibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Ganaxoloneapproved, investigationalnoenzymesubstrateDetails
Thalidomideapproved, investigational, withdrawnnoenzymesubstrateinducerDetails
Mavacamtenapproved, investigationalnoenzymesubstrateinducerDetails
Viloxazineapproved, investigational, withdrawnnoenzymeinhibitorDetails
Isoniazidapproved, investigationalunknownenzymeinhibitorDetails
Tecovirimatapproved, investigationalnoenzymeinducerDetails
Tapinarofapproved, investigationalnoenzymesubstrateDetails
Mycophenolic acidapproved, investigationalunknownenzymesubstrateDetails
GrapefruitapprovedunknownenzymeinhibitorDetails
Pirfenidoneapproved, investigationalunknownenzymeinhibitorDetails
Lenacapavirapproved, investigationalnoenzymesubstrateinhibitorDetails
Telotristat ethylapproved, investigationalnoenzymeinhibitorinducerDetails
Futibatinibapproved, investigationalnoenzymesubstrateDetails
LinzagolixapprovednoenzymesubstrateDetails
Vonoprazanapproved, investigationalunknownenzymesubstrateDetails
CobicistatapprovedyestargetinhibitorDetails
Olutasidenibapproved, investigationalnoenzymesubstrateinducerDetails
Adagrasibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Bexagliflozinapproved, investigationalunknownenzymesubstrateDetails
Pirtobrutinibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Elacestrantapproved, investigationalunknownenzymesubstrateDetails
Daprodustatapproved, investigationalnoenzymesubstrateDetails
CobicistatapprovednoenzymesubstrateDetails
Sparsentanapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Omaveloxoloneapproved, investigationalunknownenzymesubstrateinducerDetails
Zavegepantapproved, investigationalunknownenzymesubstrateDetails
Trofinetideapproved, investigationalunknownenzymeinhibitorDetails
Leniolisibapproved, investigationalnoenzymesubstrateDetails
Vadadustatapproved, investigationalunknownenzymedownregulatorDetails
Ritlecitinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Quizartinibapproved, investigationalnoenzymesubstrateDetails
Zuranoloneapproved, experimentalnoenzymesubstrateDetails
Momelotinibapproved, investigationalunknownenzymesubstrateDetails
Gepironeapproved, investigationalnoenzymesubstrateDetails
EtrasimodapprovednoenzymesubstrateDetails
Vamoroloneapproved, investigationalnoenzymesubstrateinducerDetails
Capivasertibapproved, investigationalnoenzymesubstrateDetails
Repotrectinibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Fruquintinibapproved, investigationalnoenzymesubstrateDetails
Nirogacestatapproved, investigationalnoenzymesubstrateDetails
Avatrombopagapproved, investigationalnoenzymesubstrateDetails
Aprocitentanapproved, investigationalnoenzymeinhibitorinducerDetails
Givinostatapproved, investigationalnoenzymeinhibitorinducerDetails
Tovorafenibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Mavorixaforapproved, investigationalunknownenzymesubstrateinhibitorDetails
DosulepinapprovedunknownenzymesubstrateDetails
Elafibranorapproved, investigationalunknownenzymeinducerDetails
DeuruxolitinibinvestigationalunknownenzymesubstrateDetails
Sofpironiumapproved, investigationalnoenzymesubstrateinhibitorDetails
Vorasidenibapproved, investigationalunknownenzymesubstrateinducerDetails
Seladelparapproved, investigationalunknownenzymesubstrateDetails
FerrohemeinvestigationalyestargetinhibitorDetails
Curcuminapproved, investigationalyestargetinhibitorDetails
Lazertinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Fluvoxamineapproved, investigationalunknownenzymeinhibitorDetails
Thiopentalapproved, vet_approvedunknownenzymesubstrateDetails
DolutegravirapprovednoenzymesubstrateDetails
Midostaurinapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
RheinexperimentalunknownenzymeinhibitorDetails
Diacereinapproved, investigationalunknowntargetinhibitorDetails
MyrrhapprovedunknownenzymeinducerDetails
Naldemedineapproved, investigationalnoenzymesubstrateDetails
Pibrentasvirapproved, investigationalunknownenzymeinhibitorDetails
Glecaprevirapproved, investigationalunknownenzymesubstrateinhibitorDetails
Moxisylyteapproved, investigationalnoenzymesubstrateDetails
Omega-3-carboxylic acidsapproved, investigationalnoenzymesubstrateDetails
LopinavirapprovednoenzymeinhibitorDetails
Nefazodoneapproved, withdrawnnoenzymeinhibitorDetails
Ambroxol acefyllinateexperimental, investigationalnoenzymesubstrateDetails
MirodenafilinvestigationalunknownenzymesubstrateDetails
Elagolixapproved, investigationalnoenzymesubstrateDetails
Crizotinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Acalabrutinibapproved, investigationalunknownenzymesubstrateDetails
Brigatinibapproved, investigationalunknownenzymeinducerDetails
ForetinibinvestigationalunknownenzymesubstrateDetails
Lorlatinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
PhenelzineapprovedunknownenzymeinhibitorDetails
EthosuximideapprovedunknownenzymesubstrateDetails
Rifapentineapproved, investigationalunknownenzymeinducerDetails
Mebendazoleapproved, vet_approvedunknownenzymesubstrateDetails
Istradefyllineapproved, investigationalunknownenzymeinhibitorDetails
Olanzapineapproved, investigationalunknownenzymeinhibitorDetails
LoxoprofenapprovedunknownenzymesubstrateDetails
Prednisoneapproved, vet_approvedunknownenzymeinducerDetails
BudesonideapprovedunknownenzymesubstrateinducerDetails
Methylprednisoloneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Lemborexantapproved, investigationalunknownenzymeinhibitorinducerDetails
Tazemetostatapproved, investigationalunknownenzymesubstrateDetails
Prednisolone phosphateapproved, vet_approvedunknownenzymeinducerDetails
Tucatinibapproved, investigationalunknownenzymesubstrateDetails
Zanubrutinibapproved, investigationalunknownenzymesubstrateDetails
Selpercatinibapproved, investigationalunknownenzymeinhibitorDetails
Remoxiprideapproved, withdrawnunknownenzymeinhibitorDetails
Risdiplamapproved, investigationalunknownenzymeinhibitorDetails
Lonafarnibapproved, investigationalnoenzymesubstrateinhibitorDetails
Relugolixapproved, investigationalunknownenzymesubstrateinducerDetails
Ursodeoxycholic acidapproved, investigationalunknownenzymeinducerDetails
Ebastineapproved, investigationalunknownenzymesubstrateDetails
Sotorasibapproved, investigationalunknownenzymesubstrateDetails
Quercetinexperimental, investigationalnoenzymeinhibitorDetails
Dextropropoxypheneapproved, illicit, investigational, withdrawnunknownenzymeinhibitorDetails
MethadoneapprovednoenzymeinhibitorDetails
Itraconazoleapproved, investigationalnoenzymeinhibitorDetails
Birch bark extractapproved, experimentalunknownenzymeinhibitorDetails
Letermovirapproved, investigationalnoenzymesubstrateinhibitorDetails