Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.

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Motohashi H, Inui K

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.

AAPS J. 2013 Apr;15(2):581-8. doi: 10.1208/s12248-013-9465-7. Epub 2013 Feb 22.

PubMed ID

23435786 [ View in PubMed

]

Abstract

In the kidney, human organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) are the major transporters for the secretion of cationic drugs into the urine. In the human kidney, OCT2 mediates the uptake of drugs from the blood at the basolateral membrane of tubular epithelial cells, and MATE1 and MATE2-K secrete drugs from cells into the lumen of proximal tubules. However, the expression of these transporters depends on the species of the animal. In the rodent kidney, OCT1 and OCT2 are expressed at the basolateral membrane, and MATE1 localizes at the brush-border membrane. Together, these transporters recognize various compounds and have overlapping, but somewhat different, substrate specificities. OCTs and MATEs can transport important drugs, such as metformin and cisplatin. Therefore, functional variation in OCTs and MATEs, including genetic polymorphisms or inter-individual variation, may seriously affect the pharmacokinetics and/or pharmacodynamics of cationic drugs. In this review, we summarize the recent findings and clinical importance of these transporters.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Cefradine	Multidrug and toxin extrusion protein 1	Protein	Humans	Unknown	Substrate	Details
Cephalexin	Multidrug and toxin extrusion protein 1	Protein	Humans	Unknown	Substrate	Details
Metformin	Multidrug and toxin extrusion protein 1	Protein	Humans	Unknown	Substrate	Details
Metformin	Solute carrier family 22 member 2	Protein	Humans	Unknown	Substrate Inhibitor	Details
Procainamide	Multidrug and toxin extrusion protein 1	Protein	Humans	Unknown	Substrate	Details
Procainamide	Multidrug and toxin extrusion protein 2	Protein	Humans	Unknown	Substrate	Details

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

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Abemaciclib Pyrimethamine	The excretion of Abemaciclib can be decreased when combined with Pyrimethamine.
Abemaciclib Lofexidine	The excretion of Abemaciclib can be decreased when combined with Lofexidine.
Abemaciclib Tafenoquine	The excretion of Abemaciclib can be decreased when combined with Tafenoquine.
Abemaciclib Bictegravir	The excretion of Abemaciclib can be decreased when combined with Bictegravir.
Abemaciclib Gilteritinib	The excretion of Abemaciclib can be decreased when combined with Gilteritinib.
Abemaciclib Plazomicin	The excretion of Abemaciclib can be decreased when combined with Plazomicin.
Abemaciclib Pexidartinib	The excretion of Abemaciclib can be decreased when combined with Pexidartinib.
Abemaciclib Flecainide	The excretion of Abemaciclib can be decreased when combined with Flecainide.
Abemaciclib Tazemetostat	The excretion of Abemaciclib can be decreased when combined with Tazemetostat.
Abemaciclib Selpercatinib	The excretion of Abemaciclib can be decreased when combined with Selpercatinib.

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