Bisphosphonates: mechanism of action and role in clinical practice.
Article Details
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Drake MT, Clarke BL, Khosla S
Bisphosphonates: mechanism of action and role in clinical practice.
Mayo Clin Proc. 2008 Sep;83(9):1032-45. doi: 10.4065/83.9.1032.
- PubMed ID
- 18775204 [ View in PubMed]
- Abstract
Bisphosphonates are primary agents in the current pharmacological arsenal against osteoclast-mediated bone loss due to osteoporosis, Paget disease of bone, malignancies metastatic to bone, multiple myeloma, and hypercalcemia of malignancy. In addition to currently approved uses, bisphosphonates are commonly prescribed for prevention and treatment of a variety of other skeletal conditions, such as low bone density and osteogenesis imperfecta. However, the recent recognition that bisphosphonate use is associated with pathologic conditions including osteonecrosis of the jaw has sharpened the level of scrutiny of the current widespread use of bisphosphonate therapy. Using the key words bisphosphonate and clinical practice in a PubMed literature search from January 1, 1998, to May 1, 2008, we review current understanding of the mechanisms by which bisphosphonates exert their effects on osteoclasts, discuss the role of bisphosphonates in clinical practice, and highlight some areas of concern associated with bisphosphonate use.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tiludronic acid Hydroxylapatite Small molecule Humans YesAntagonistBinderDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareParathyroid hormonePamidronic acid The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Pamidronic acid. Parathyroid hormoneZoledronic acid The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Zoledronic acid. Parathyroid hormoneAlendronic acid The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Alendronic acid. Parathyroid hormoneIbandronate The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Ibandronate. Parathyroid hormoneClodronic acid The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Clodronic acid.