DNA sequence and analysis of human chromosome 18.

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Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES

DNA sequence and analysis of human chromosome 18.

Nature. 2005 Sep 22;437(7058):551-5.

PubMed ID
16177791 [ View in PubMed
]
Abstract

Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Histamine H4 receptorQ9H3N8Details
NAD-dependent malic enzyme, mitochondrialP23368Details
Apoptosis regulator Bcl-2P10415Details
Thymidylate synthaseP04818Details
Asparagine--tRNA ligase, cytoplasmicO43776Details
Tyrosine-protein kinase YesP07947Details
Cytochrome b5P00167Details
Serpin B5P36952Details
Laminin subunit alpha-1P25391Details
Laminin subunit alpha-3Q16787Details
Molybdenum cofactor sulfuraseQ96EN8Details
ATP synthase subunit alpha, mitochondrialP25705Details
Serpin B3P29508Details
Urea transporter 2Q15849Details
Nuclear factor of activated T-cells, cytoplasmic 1O95644Details
Ubiquitin carboxyl-terminal hydrolase 14P54578Details
Mitogen-activated protein kinase 4P31152Details
Serine/threonine-protein kinase RIO3O14730Details
Zinc transporter ZIP6Q13433Details