DNA sequence and analysis of human chromosome 18.
Article Details
- CitationCopy to clipboard
Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES
DNA sequence and analysis of human chromosome 18.
Nature. 2005 Sep 22;437(7058):551-5.
- PubMed ID
- 16177791 [ View in PubMed]
- Abstract
Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Histamine H4 receptor Q9H3N8 Details NAD-dependent malic enzyme, mitochondrial P23368 Details Apoptosis regulator Bcl-2 P10415 Details Thymidylate synthase P04818 Details Asparagine--tRNA ligase, cytoplasmic O43776 Details Tyrosine-protein kinase Yes P07947 Details Cytochrome b5 P00167 Details Serpin B5 P36952 Details Laminin subunit alpha-1 P25391 Details Laminin subunit alpha-3 Q16787 Details Molybdenum cofactor sulfurase Q96EN8 Details ATP synthase subunit alpha, mitochondrial P25705 Details Serpin B3 P29508 Details Urea transporter 2 Q15849 Details Nuclear factor of activated T-cells, cytoplasmic 1 O95644 Details Ubiquitin carboxyl-terminal hydrolase 14 P54578 Details Mitogen-activated protein kinase 4 P31152 Details Serine/threonine-protein kinase RIO3 O14730 Details Zinc transporter ZIP6 Q13433 Details