Urea transporter 2

Details

Name
Urea transporter 2
Synonyms
  • HUT2
  • Solute carrier family 14 member 2
  • Urea transporter, kidney
  • UT2
Gene Name
SLC14A2
UniProtKB Entry
Q15849Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0008542|Urea transporter 2
MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSH
IVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFID
WVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASG
LHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPF
NIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPW
TGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGM
FYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIF
RLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFH
IEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTS
WIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSG
ILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSD
KGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFF
PTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICL
HAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALF
AAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYL
SQERNRRASIITKYQAYDVS
Number of residues
920
Molecular Weight
101207.965
Theoretical pI
Not Available
GO Classification
Functions
cell adhesion molecule binding / urea transmembrane transporter activity
Processes
transmembrane transport / urea transmembrane transport / urea transport
Components
apical plasma membrane / membrane / plasma membrane
General Function
Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism
Specific Function
cell adhesion molecule binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
151-170 176-196 204-224 233-253 272-291 302-322 346-366 370-390 392-412 600-620 638-658 666-686 695-715 764-784 803-823 832-852 854-874
Cellular Location
Apical cell membrane
Gene sequence
>lcl|BSEQ0013263|Urea transporter 2 (SLC14A2)
ATGTCTGACCCCCACAGCAGTCCTCTCCTGCCAGAGCCACTTTCCAGCAGATACAAACTC
TACGAGGCAGAGTTTACCAGCCCGAGCTGGCCCTCGACATCCCCGGATACTCACCCAGCT
CTGCCCCTCCTGGAAATGCCTGAAGAAAAGGATCTCCGGTCTTCCAATGAAGACAGTCAC
ATTGTGAAGATCGAAAAGCTCAATGAAAGGAGTAAAAGGAAAGACGACGGGGTGGCCCAT
CGGGACTCAGCAGGCCAAAGGTGCATCTGCCTCTCCAAAGCAGTGGGCTACCTCACGGGC
GACATGAAGGAGTACAGGATCTGGCTGAAAGACAAGCACCTTGCCCTCCAGTTCATAGAC
TGGGTCCTGAGAGGGACCGCTCAGGTGATGTTCATCAACAATCCTCTCAGCGGCCTCATC
ATCTTCATAGGGCTGCTGATCCAGAATCCCTGGTGGACAATCACTGGGGGCCTGGGGACA
GTGGTCTCGACCTTAACAGCTCTCGCCTTGGGCCAAGACAGGTCTGCCATTGCCTCAGGA
CTCCATGGGTACAACGGGATGCTGGTGGGACTGCTGATGGCCGTGTTCTCGGAGAAGTTA
GACTACTACTGGTGGCTTCTGTTTCCTGTGACCTTCACAGCCATGTCCTGCCCAGTTCTT
TCTAGTGCCTTGAATTCCATCTTCAGCAAGTGGGACCTCCCGGTCTTCACTCTGCCCTTC
AACATTGCAGTCACCTTGTACCTTGCAGCCACAGGCCACTACAACCTCTTCTTCCCCACA
ACACTGGTAGAGCCTGTGTCTTCAGTGCCCAATATCACCTGGACAGAGATGGAAATGCCC
CTGCTGTTACAAGCCATCCCTGTTGGGGTCGGCCAGGTGTATGGCTGTGACAATCCCTGG
ACAGGCGGCGTGTTCCTGGTGGCTCTGTTCATCTCCTCGCCACTCATCTGCTTGCATGCA
GCCATTGGCTCAATCGTGGGGCTGCTAGCAGCCCTGTCAGTGGCCACACCCTTCGAGACC
ATCTACACAGGCCTCTGGAGCTACAACTGCGTCCTCTCCTGCATCGCCATCGGAGGCATG
TTCTATGCCCTCACCTGGCAGACTCACCTGCTGGCCCTCATCTGTGCCCTGTTCTGTGCA
TACATGGAAGCAGCCATCTCCAACATCATGTCAGTGGTGGGCGTGCCACCAGGCACCTGG
GCCTTCTGCCTTGCCACCATCATCTTCCTGCTCCTGACGACAAACAACCCAGCCATCTTC
AGACTCCCACTCAGCAAAGTCACCTACCCCGAGGCCAACCGCATCTACTACCTGACAGTG
AAAAGCGGTGAAGAAGAGAAGGCCCCCAGCGGAGGCGGTGGGGAGCATCCACCCACAGCA
GGCCCAAAGGTGGAGGAGGGCTCGGAGGCTGTGCTCTCCAAGCACAGGAGTGTATTTCAC
ATCGAGTGGTCATCCATTCGGAGGAGGAGCAAAGTGTTTGGAAAAGGCGAACACCAGGAA
AGACAAAACAAAGACCCATTTCCCTATCGATACCGGAAGCCCACAGTCGAGCTGCTTGAT
CTGGACACCATGGAGGAGAGCTCTGAGATAAAAGTGGAAACAAACATTTCCAAGACATCC
TGGATTCGGAGTTCCATGGCTGCCAGTGGGAAAAGGGTCAGCAAAGCCCTCAGCTACATC
ACAGGAGAGATGAAGGAGTGTGGAGAGGGACTTAAAGACAAGTCCCCAGTGTTCCAGTTC
TTTGACTGGGTCCTCCGAGGCACATCTCAAGTGATGTTTGTGAACAACCCCCTCAGCGGC
ATCCTCATCATCCTCGGCCTCTTCATCCAGAACCCCTGGTGGGCGATCTCAGGCTGCCTG
GGTACCATCATGTCCACCTTGACAGCCCTCATCCTGAGTCAGGACAAGTCGGCCATCGCT
GCAGGATTTCACGGCTACAATGGGGTGCTGGTGGGGCTGCTGATGGCCGTGTTCTCAGAC
AAAGGTGACTACTACTGGTGGCTGTTGCTACCCGTCATCATCATGTCCATGTCTTGCCCC
ATCCTCTCCAGTGCCCTGGGTACCATCTTCAGCAAGTGGGACCTCCCAGTCTTCACACTG
CCCTTCAATATCACTGTGACTTTGTACCTGGCAGCCACGGGCCACTACAACCTTTTCTTC
CCCACAACGCTGCTGCAGCCTGCATCCGCCATGCCCAACATCACCTGGTCAGAGGTCCAA
GTGCCCTTGCTTTTGAGAGCCATCCCCGTTGGAATTGGCCAAGTGTACGGCTGTGATAAC
CCCTGGACTGGAGGCATCTTCCTCATAGCTCTGTTCATATCCTCACCTCTCATTTGCTTG
CATGCAGCAATTGGATCCACCATGGGGATGCTAGCAGCACTCACTATTGCGACGCCCTTT
GACTCCATCTACTTCGGCCTGTGTGGCTTCAACAGCACCCTCGCATGCATAGCGATAGGA
GGCATGTTCTACGTCATCACCTGGCAGACGCACCTCCTCGCCATCGCCTGCGCACTGTTT
GCTGCCTACCTGGGTGCTGCCCTGGCTAACATGTTATCTGTGTTTGGATTGCCGCCCTGC
ACTTGGCCCTTCTGTCTCTCAGCTCTCACCTTCCTGCTCCTGACGACCAATAACCCCGCC
ATCTACAAGCTCCCGCTCAGCAAAGTCACCTACCCAGAGGCCAACCGCATCTACTACCTG
TCCCAGGAGAGAAACAGAAGGGCATCAATCATAACAAAGTATCAGGCCTACGATGTCTCC
TAA
Chromosome Location
18
Locus
18q12.3
External Identifiers
ResourceLink
UniProtKB IDQ15849
UniProtKB Entry NameUT2_HUMAN
GeneCard IDSLC14A2
HGNC IDHGNC:10919
PDB ID(s)8BLO
KEGG IDhsa:8170
NCBI Gene ID8170
General References
  1. Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P: Molecular characterization of a new urea transporter in the human kidney. FEBS Lett. 1996 May 20;386(2-3):156-60. [Article]
  2. Bagnasco SM, Peng T, Janech MG, Karakashian A, Sands JM: Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001 Sep;281(3):F400-6. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Mistry AC, Mallick R, Frohlich O, Klein JD, Rehm A, Chen G, Sands JM: The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J Biol Chem. 2007 Oct 12;282(41):30097-106. Epub 2007 Aug 16. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Urea transporter 2 (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Ureaapproved, investigationalunknowntransportersubstrateDetails
HydroxyureaapprovednotransportersubstrateDetails