Urea transporter 2
Details
- Name
- Urea transporter 2
- Synonyms
- HUT2
- Solute carrier family 14 member 2
- Urea transporter, kidney
- UT2
- Gene Name
- SLC14A2
- UniProtKB Entry
- Q15849Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008542|Urea transporter 2 MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSH IVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFID WVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASG LHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPF NIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPW TGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGM FYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIF RLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFH IEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTS WIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSG ILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSD KGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFF PTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICL HAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALF AAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYL SQERNRRASIITKYQAYDVS
- Number of residues
- 920
- Molecular Weight
- 101207.965
- Theoretical pI
- Not Available
- GO Classification
- Functionscell adhesion molecule binding / urea transmembrane transporter activityProcessestransmembrane transport / urea transmembrane transport / urea transportComponentsapical plasma membrane / membrane / plasma membrane
- General Function
- Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism
- Specific Function
- cell adhesion molecule binding
- Pfam Domain Function
- UT (PF03253)
- Signal Regions
- Not Available
- Transmembrane Regions
- 151-170 176-196 204-224 233-253 272-291 302-322 346-366 370-390 392-412 600-620 638-658 666-686 695-715 764-784 803-823 832-852 854-874
- Cellular Location
- Apical cell membrane
- Gene sequence
>lcl|BSEQ0013263|Urea transporter 2 (SLC14A2) ATGTCTGACCCCCACAGCAGTCCTCTCCTGCCAGAGCCACTTTCCAGCAGATACAAACTC TACGAGGCAGAGTTTACCAGCCCGAGCTGGCCCTCGACATCCCCGGATACTCACCCAGCT CTGCCCCTCCTGGAAATGCCTGAAGAAAAGGATCTCCGGTCTTCCAATGAAGACAGTCAC ATTGTGAAGATCGAAAAGCTCAATGAAAGGAGTAAAAGGAAAGACGACGGGGTGGCCCAT CGGGACTCAGCAGGCCAAAGGTGCATCTGCCTCTCCAAAGCAGTGGGCTACCTCACGGGC GACATGAAGGAGTACAGGATCTGGCTGAAAGACAAGCACCTTGCCCTCCAGTTCATAGAC TGGGTCCTGAGAGGGACCGCTCAGGTGATGTTCATCAACAATCCTCTCAGCGGCCTCATC ATCTTCATAGGGCTGCTGATCCAGAATCCCTGGTGGACAATCACTGGGGGCCTGGGGACA GTGGTCTCGACCTTAACAGCTCTCGCCTTGGGCCAAGACAGGTCTGCCATTGCCTCAGGA CTCCATGGGTACAACGGGATGCTGGTGGGACTGCTGATGGCCGTGTTCTCGGAGAAGTTA GACTACTACTGGTGGCTTCTGTTTCCTGTGACCTTCACAGCCATGTCCTGCCCAGTTCTT TCTAGTGCCTTGAATTCCATCTTCAGCAAGTGGGACCTCCCGGTCTTCACTCTGCCCTTC AACATTGCAGTCACCTTGTACCTTGCAGCCACAGGCCACTACAACCTCTTCTTCCCCACA ACACTGGTAGAGCCTGTGTCTTCAGTGCCCAATATCACCTGGACAGAGATGGAAATGCCC CTGCTGTTACAAGCCATCCCTGTTGGGGTCGGCCAGGTGTATGGCTGTGACAATCCCTGG ACAGGCGGCGTGTTCCTGGTGGCTCTGTTCATCTCCTCGCCACTCATCTGCTTGCATGCA GCCATTGGCTCAATCGTGGGGCTGCTAGCAGCCCTGTCAGTGGCCACACCCTTCGAGACC ATCTACACAGGCCTCTGGAGCTACAACTGCGTCCTCTCCTGCATCGCCATCGGAGGCATG TTCTATGCCCTCACCTGGCAGACTCACCTGCTGGCCCTCATCTGTGCCCTGTTCTGTGCA TACATGGAAGCAGCCATCTCCAACATCATGTCAGTGGTGGGCGTGCCACCAGGCACCTGG GCCTTCTGCCTTGCCACCATCATCTTCCTGCTCCTGACGACAAACAACCCAGCCATCTTC AGACTCCCACTCAGCAAAGTCACCTACCCCGAGGCCAACCGCATCTACTACCTGACAGTG AAAAGCGGTGAAGAAGAGAAGGCCCCCAGCGGAGGCGGTGGGGAGCATCCACCCACAGCA GGCCCAAAGGTGGAGGAGGGCTCGGAGGCTGTGCTCTCCAAGCACAGGAGTGTATTTCAC ATCGAGTGGTCATCCATTCGGAGGAGGAGCAAAGTGTTTGGAAAAGGCGAACACCAGGAA AGACAAAACAAAGACCCATTTCCCTATCGATACCGGAAGCCCACAGTCGAGCTGCTTGAT CTGGACACCATGGAGGAGAGCTCTGAGATAAAAGTGGAAACAAACATTTCCAAGACATCC TGGATTCGGAGTTCCATGGCTGCCAGTGGGAAAAGGGTCAGCAAAGCCCTCAGCTACATC ACAGGAGAGATGAAGGAGTGTGGAGAGGGACTTAAAGACAAGTCCCCAGTGTTCCAGTTC TTTGACTGGGTCCTCCGAGGCACATCTCAAGTGATGTTTGTGAACAACCCCCTCAGCGGC ATCCTCATCATCCTCGGCCTCTTCATCCAGAACCCCTGGTGGGCGATCTCAGGCTGCCTG GGTACCATCATGTCCACCTTGACAGCCCTCATCCTGAGTCAGGACAAGTCGGCCATCGCT GCAGGATTTCACGGCTACAATGGGGTGCTGGTGGGGCTGCTGATGGCCGTGTTCTCAGAC AAAGGTGACTACTACTGGTGGCTGTTGCTACCCGTCATCATCATGTCCATGTCTTGCCCC ATCCTCTCCAGTGCCCTGGGTACCATCTTCAGCAAGTGGGACCTCCCAGTCTTCACACTG CCCTTCAATATCACTGTGACTTTGTACCTGGCAGCCACGGGCCACTACAACCTTTTCTTC CCCACAACGCTGCTGCAGCCTGCATCCGCCATGCCCAACATCACCTGGTCAGAGGTCCAA GTGCCCTTGCTTTTGAGAGCCATCCCCGTTGGAATTGGCCAAGTGTACGGCTGTGATAAC CCCTGGACTGGAGGCATCTTCCTCATAGCTCTGTTCATATCCTCACCTCTCATTTGCTTG CATGCAGCAATTGGATCCACCATGGGGATGCTAGCAGCACTCACTATTGCGACGCCCTTT GACTCCATCTACTTCGGCCTGTGTGGCTTCAACAGCACCCTCGCATGCATAGCGATAGGA GGCATGTTCTACGTCATCACCTGGCAGACGCACCTCCTCGCCATCGCCTGCGCACTGTTT GCTGCCTACCTGGGTGCTGCCCTGGCTAACATGTTATCTGTGTTTGGATTGCCGCCCTGC ACTTGGCCCTTCTGTCTCTCAGCTCTCACCTTCCTGCTCCTGACGACCAATAACCCCGCC ATCTACAAGCTCCCGCTCAGCAAAGTCACCTACCCAGAGGCCAACCGCATCTACTACCTG TCCCAGGAGAGAAACAGAAGGGCATCAATCATAACAAAGTATCAGGCCTACGATGTCTCC TAA
- Chromosome Location
- 18
- Locus
- 18q12.3
- External Identifiers
Resource Link UniProtKB ID Q15849 UniProtKB Entry Name UT2_HUMAN GeneCard ID SLC14A2 HGNC ID HGNC:10919 PDB ID(s) 8BLO KEGG ID hsa:8170 NCBI Gene ID 8170 - General References
- Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P: Molecular characterization of a new urea transporter in the human kidney. FEBS Lett. 1996 May 20;386(2-3):156-60. [Article]
- Bagnasco SM, Peng T, Janech MG, Karakashian A, Sands JM: Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001 Sep;281(3):F400-6. [Article]
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- Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [Article]
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- Mistry AC, Mallick R, Frohlich O, Klein JD, Rehm A, Chen G, Sands JM: The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J Biol Chem. 2007 Oct 12;282(41):30097-106. Epub 2007 Aug 16. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Urea transporter 2 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Urea approved, investigational unknown transporter substrate Details Hydroxyurea approved no transporter substrate Details