Alitretinoin: a comprehensive review.

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Cheng C, Michaels J, Scheinfeld N

Alitretinoin: a comprehensive review.

Expert Opin Investig Drugs. 2008 Mar;17(3):437-43. doi: 10.1517/13543784.17.3.437 .

PubMed ID

18321241 [ View in PubMed

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Abstract

BACKGROUND: Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carried out to determine how best to utilize this characteristic in treatments for conditions such as chronic hand dermatitis. OBJECTIVE: To review the literature on alitretinoin. METHODS: The scope of the review encompasses ways that alitretinoin is currently and may potentially be utilized. RESULTS/CONCLUSIONS: Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. Topical treatment with alitretinoin can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Alitretinoin	Retinoic acid receptor alpha	Protein	Humans	Yes	Agonist	Details
Alitretinoin	Retinoic acid receptor RXR-alpha	Protein	Humans	Yes	Agonist	Details
Alitretinoin	Retinoic acid receptor RXR-beta	Protein	Humans	Yes	Agonist	Details