Retinoic acid receptor RXR-alpha

Details

Name
Retinoic acid receptor RXR-alpha
Synonyms
  • NR2B1
  • Nuclear receptor subfamily 2 group B member 1
  • Retinoid X receptor alpha
Gene Name
RXRA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000821|Retinoic acid receptor RXR-alpha
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Number of residues
462
Molecular Weight
50810.835
Theoretical pI
7.86
GO Classification
Functions
9-cis retinoic acid receptor activity / chromatin DNA binding / DNA binding / enzyme binding / protein heterodimerization activity / retinoic acid receptor activity / retinoic acid-responsive element binding / RNA polymerase II regulatory region sequence-specific DNA binding / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding / sequence-specific DNA binding / steroid hormone receptor activity / transcription coactivator activity / transcription factor activity, sequence-specific DNA binding / vitamin D receptor binding / zinc ion binding
Processes
aging / axon regeneration / bile acid and bile salt transport / bile acid metabolic process / camera-type eye development / cellular lipid metabolic process / cellular response to insulin stimulus / cholesterol metabolic process / embryo implantation / gene expression / in utero embryonic development / inflammatory response / liver development / maternal placenta development / midgut development / modulation by virus of host morphology or physiology / negative regulation of cell proliferation / negative regulation of transcription from RNA polymerase II promoter / peroxisome proliferator activated receptor signaling pathway / positive regulation of apoptotic process / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus / positive regulation of translational initiation by iron / protein homotetramerization / regulation of branching involved in prostate gland morphogenesis / regulation of myelination / response to ethanol / response to glucocorticoid / response to retinoic acid / response to selenium ion / response to vitamin A / response to vitamin D / retinoic acid receptor signaling pathway / secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development / small molecule metabolic process / transcription initiation from RNA polymerase II promoter / ventricular cardiac muscle cell differentiation / ventricular cardiac muscle tissue morphogenesis / vitamin metabolic process
Components
axon / nuclear chromatin / nucleoplasm / nucleus / receptor complex / RNA polymerase II transcription factor complex
General Function
Zinc ion binding
Specific Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0000820|1389 bp
ATGGACACCAAACATTTCCTGCCGCTCGATTTCTCCACCCAGGTGAACTCCTCCCTCACC
TCCCCGACGGGGCGAGGCTCCATGGCTGCCCCCTCGCTGCACCCGTCCCTGGGGCCTGGC
ATCGGCTCCCCGGGACAGCTGCATTCTCCCATCAGCACCCTGAGCTCCCCCATCAACGGC
ATGGGCCCGCCTTTCTCGGTCATCAGCTCCCCCATGGGCCCCCACTCCATGTCGGTGCCC
ACCACACCCACCCTGGGCTTCAGCACTGGCAGCCCCCAGCTCAGCTCACCTATGAACCCC
GTCAGCAGCAGCGAGGACATCAAGCCCCCCCTGGGCCTCAATGGCGTCCTCAAGGTCCCC
GCCCACCCCTCAGGAAACATGGCTTCCTTCACCAAGCACATCTGCGCCATCTGCGGGGAC
CGCTCCTCAGGCAAGCACTATGGAGTGTACAGCTGCGAGGGGTGCAAGGGCTTCTTCAAG
CGGACGGTGCGCAAGGACCTGACCTACACCTGCCGCGACAACAAGGACTGCCTGATTGAC
AAGCGGCAGCGGAACCGGTGCCAGTACTGCCGCTACCAGAAGTGCCTGGCCATGGGCATG
AAGCGGGAAGCCGTGCAGGAGGAGCGGCAGCGTGGCAAGGACCGGAACGAGAATGAGGTG
GAGTCGACCAGCAGCGCCAACGAGGACATGCCGGTGGAGAGGATCCTGGAGGCTGAGCTG
GCCGTGGAGCCCAAGACCGAGACCTACGTGGAGGCAAACATGGGGCTGAACCCCAGCTCG
CCGAACGACCCTGTCACCAACATTTGCCAAGCAGCCGACAAACAGCTTTTCACCCTGGTG
GAGTGGGCCAAGCGGATCCCACACTTCTCAGAGCTGCCCCTGGACGACCAGGTCATCCTG
CTGCGGGCAGGCTGGAATGAGCTGCTCATCGCCTCCTTCTCCCACCGCTCCATCGCCGTG
AAGGACGGGATCCTCCTGGCCACCGGGCTGCACGTCCACCGGAACAGCGCCCACAGCGCA
GGGGTGGGCGCCATCTTTGACAGGGTGCTGACGGAGCTTGTGTCCAAGATGCGGGACATG
CAGATGGACAAGACGGAGCTGGGCTGCCTGCGCGCCATCGTCCTCTTTAACCCTGACTCC
AAGGGGCTCTCGAACCCGGCCGAGGTGGAGGCGCTGAGGGAGAAGGTCTATGCGTCCTTG
GAGGCCTACTGCAAGCACAAGTACCCAGAGCAGCCGGGAAGGTTCGCTAAGCTCTTGCTC
CGCCTGCCGGCTCTGCGCTCCATCGGGCTCAAATGCCTGGAACATCTCTTCTTCTTCAAG
CTCATCGGGGACACACCCATTGACACCTTCCTTATGGAGATGCTGGAGGCGCCGCACCAA
ATGACTTAG
Chromosome Location
Not Available
Locus
9q34.3
External Identifiers
ResourceLink
UniProtKB IDP19793
UniProtKB Entry NameRXRA_HUMAN
GenBank Protein ID35885
GenBank Gene IDX52773
GenAtlas IDRXRA
HGNC IDHGNC:10477
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00459AcitretinapprovedyesagonistDetails
DB00523Alitretinoinapproved, investigationalyesagonistDetails
DB00926EtretinatewithdrawnyesagonistDetails
DB05956EVT-101investigationalunknownDetails
DB00749Etodolacapproved, investigational, vet_approvedunknownotherDetails
DB00307Bexaroteneapproved, investigationalyesagonistDetails
DB075573,20-PregnanedioneexperimentalunknownDetails
DB078632-chloro-5-nitro-N-phenylbenzamideexperimentalunknownDetails
DB080631-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONEexperimentalunknownDetails
DB084022-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDexperimentalunknownDetails
DB08601TributyltinexperimentalunknownDetails
DB03756Doconexentapproved, investigationalyesactivatorDetails
DB04557Arachidonic AcidexperimentalunknownDetails
DB00132alpha-Linolenic acidapproved, investigational, nutraceuticalunknownDetails
DB04224Oleic Acidapproved, investigational, vet_approvedunknownDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownDetails
DB01436Alfacalcidolapproved, nutraceuticalunknownDetails
DB01393Bezafibrateapproved, investigationalunknownagonistDetails
DB02746Phthalic AcidexperimentalunknownDetails
DB00412Rosiglitazoneapproved, investigationalunknownDetails
DB00210AdapaleneapprovedyesagonistDetails