Receptor specificity of the fibroblast growth factor family.
Article Details
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Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M
Receptor specificity of the fibroblast growth factor family.
J Biol Chem. 1996 Jun 21;271(25):15292-7.
- PubMed ID
- 8663044 [ View in PubMed]
- Abstract
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual FGF receptors. To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. Using FGF 1 as an internal standard we have determined the relative activity of all the other members of the FGF family. These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Palifermin Fibroblast growth factor receptor 1 Protein Humans UnknownAgonistDetails Palifermin Fibroblast growth factor receptor 2 Protein Humans YesAgonistBinderDetails - Polypeptides
Name UniProt ID Fibroblast growth factor 4 P08620 Details Fibroblast growth factor 1 P05230 Details Fibroblast growth factor receptor 2 P21802 Details Fibroblast growth factor 2 P09038 Details Fibroblast growth factor receptor 4 P22455 Details Fibroblast growth factor receptor 1 P11362 Details Fibroblast growth factor receptor 3 P22607 Details