Receptor specificity of the fibroblast growth factor family.

Article Details


Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M

Receptor specificity of the fibroblast growth factor family.

J Biol Chem. 1996 Jun 21;271(25):15292-7.

PubMed ID
8663044 [ View in PubMed

Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual FGF receptors. To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. Using FGF 1 as an internal standard we have determined the relative activity of all the other members of the FGF family. These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
PaliferminFibroblast growth factor receptor 1ProteinHumans
PaliferminFibroblast growth factor receptor 2ProteinHumans
NameUniProt ID
Fibroblast growth factor 4P08620Details
Fibroblast growth factor 1P05230Details
Fibroblast growth factor receptor 2P21802Details
Fibroblast growth factor 2P09038Details
Fibroblast growth factor receptor 4P22455Details
Fibroblast growth factor receptor 1P11362Details
Fibroblast growth factor receptor 3P22607Details