Receptor specificity of the fibroblast growth factor family.

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Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M

Receptor specificity of the fibroblast growth factor family.

J Biol Chem. 1996 Jun 21;271(25):15292-7.

PubMed ID

8663044 [ View in PubMed

]

Abstract

Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual FGF receptors. To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. Using FGF 1 as an internal standard we have determined the relative activity of all the other members of the FGF family. These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways.

DrugBank Data that Cites this Article

Drugs

Palifermin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Palifermin	Fibroblast growth factor receptor 1	Protein	Humans	Unknown	Agonist	Details
Palifermin	Fibroblast growth factor receptor 2	Protein	Humans	Yes	Agonist Binder	Details

Polypeptides

Name	UniProt ID
Fibroblast growth factor 4	P08620	Details
Fibroblast growth factor 1	P05230	Details
Fibroblast growth factor receptor 2	P21802	Details
Fibroblast growth factor 2	P09038	Details
Fibroblast growth factor receptor 4	P22455	Details
Fibroblast growth factor receptor 1	P11362	Details
Fibroblast growth factor receptor 3	P22607	Details