Fibroblast growth factor 2
Details
- Name
- Fibroblast growth factor 2
- Synonyms
- Basic fibroblast growth factor
- bFGF
- FGF-2
- FGFB
- HBGF-2
- Heparin-binding growth factor 2
- Gene Name
- FGF2
- UniProtKB Entry
- P09038Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037112|Fibroblast growth factor 2 MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAA GSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAA PAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG RVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERL ESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
- Number of residues
- 288
- Molecular Weight
- 30769.715
- Theoretical pI
- 10.01
- GO Classification
- Functionschemokine binding / identical protein binding / integrin binding / nuclear receptor coactivator activity / receptor-receptor interactionProcessesangiogenesis involved in coronary vascular morphogenesis / animal organ morphogenesis / canonical Wnt signaling pathway / cell differentiation / cellular response to mechanical stimulus / cerebellar granule cell precursor proliferation / corticotropin hormone secreting cell differentiation / embryo development ending in birth or egg hatching / endothelial cell proliferation / ERK1 and ERK2 cascade / glial cell differentiation / inner ear auditory receptor cell differentiation / lung development / lymphatic endothelial cell migration / mammary gland epithelial cell differentiation / negative regulation of fibroblast growth factor receptor signaling pathway / negative regulation of gene expression / negative regulation of stem cell proliferation / neuroblast proliferation / organ induction / osteoblast differentiation / paracrine signaling / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of canonical Wnt signaling pathway / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of cell population proliferation / positive regulation of cerebellar granule cell precursor proliferation / positive regulation of DNA biosynthetic process / positive regulation of DNA-templated transcription / positive regulation of endothelial cell chemotaxis / positive regulation of endothelial cell migration / positive regulation of epithelial tube formation / positive regulation of gene expression / positive regulation of inner ear auditory receptor cell differentiation / positive regulation of lens fiber cell differentiation / positive regulation of MAPK cascade / positive regulation of miRNA transcription / positive regulation of neuroblast proliferation / positive regulation of neuroepithelial cell differentiation / positive regulation of osteoblast differentiation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of stem cell differentiation / positive regulation of stem cell proliferation / positive regulation of transcription by RNA polymerase II / positive regulation of vascular associated smooth muscle cell proliferation / positive regulation of vascular endothelial cell proliferation / regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / regulation of cell cycle / regulation of cell migration / regulation of cell migration involved in sprouting angiogenesis / regulation of retinal cell programmed cell death / response to axon injury / stem cell development / stem cell proliferation / substantia nigra development / thyroid-stimulating hormone-secreting cell differentiation / transcription by RNA polymerase IIComponentscytoplasm
- General Function
- Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879)
- Specific Function
- chemoattractant activity
- Pfam Domain Function
- FGF (PF00167)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0021843|Fibroblast growth factor 2 (FGF2) CTGGTGGGTGTGGGGGGTGGAGATGTAGAAGATGTGACGCCGCGGCCCGGCGGGTGCCAG ATTAGCGGACGCGGTGCCCGCGGTTGCAACGGGATCCCGGGCGCTGCAGCTTGGGAGGCG GCTCTCCCCAGGCGGCGTCCGCGGAGACACCCATCCGTGAACCCCAGGTCCCGGGCCGCC GGCTCGCCGCGCACCAGGGGCCGGCGGACAGAAGAGCGGCCGAGCGGCTCGAGGCTGGGG GACCGCGGGCGCGGCCGCGCGCTGCCGGGCGGGAGGCTGGGGGGCCGGGGCCGGGGCCGT GCCCCGGAGCGGGTCGGAGGCCGGGGCCGGGGCCGGGGGACGGCGGCTCCCCGCGCGGCT CCAGCGGCTCGGGGATCCCGGCCGGGCCCCGCAGGGACCATGGCAGCCGGGAGCATCACC ACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCCTTCCCGCCCGGCCACTTCAAG GACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGC CGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACATCAAGCTACAACTTCAAGCAGAA GAGAGAGGAGTTGTGTCTATCAAAGGAGTGTGTGCTAACCGTTACCTGGCTATGAAGGAA GATGGAAGATTACTGGCTTCTAAATGTGTTACGGATGAGTGTTTCTTTTTTGAACGATTG GAATCTAATAACTACAATACTTACCGGTCAAGGAAATACACCAGTTGGTATGTGGCACTG AAACGAACTGGGCAGTATAAACTTGGATCCAAAACAGGACCTGGGCAGAAAGCTATACTT TTTCTTCCAATGTCTGCTAAGAGCTGA
- Chromosome Location
- 4
- Locus
- 4q28.1
- External Identifiers
Resource Link UniProtKB ID P09038 UniProtKB Entry Name FGF2_HUMAN GenBank Protein ID 31362 GenBank Gene ID X04431 GeneCard ID FGF2 GenAtlas ID FGF2 HGNC ID HGNC:3676 PDB ID(s) 1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG, 5X1O, 6L4O, 8OM6 KEGG ID hsa:2247 NCBI Gene ID 2247 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Fibroblast growth factor 2 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Pentosan polysulfate approved yes target antagonist Details 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid experimental unknown target Details N,O6-Disulfo-Glucosamine experimental yes target inhibitor Details 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid experimental unknown target Details ABT-510 investigational unknown target Details Sucralfate approved yes target agonistinducer Details Heparin approved, investigational unknown target Details Mercaptoethanol experimental yes target inhibitor Details Squalamine investigational yes target modulator Details