Muscarinic mediation of the urethro genital reflex in spinal cord-transected rats.
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Gil L, Gomez LE, Duran I, Cueva-Rolon R
Muscarinic mediation of the urethro genital reflex in spinal cord-transected rats.
Pharmacol Biochem Behav. 2000 Oct;67(2):215-23.
- PubMed ID
- 11124384 [ View in PubMed]
- Abstract
The effects of muscarinic receptor stimulation were tested on the urethro genital reflex (UGR) in anesthetized and spinal cord-transected rats. Drugs were applied directly to the spinal cord. The electromyographic activity (EMG) of the bulbospongiosus (BS) muscle was used for recording UGR. In six animals BS as well as soleus, posterior biceps or peroneus tertius muscle EMG was recorded simultaneously. Muscarine (5, 10, 20, 50 and 100 microg) was applied in 22 animals after cutting L6-S1 dorsal roots. Some observations were made on another six animals, to which an extensive bilateral dorsal rhizotomy (L3-S2) was performed. Rhythmic bursts of similar frequency and size to those seen during UGR were found in BS muscle a few minutes after muscarine application. No rhythmic bursting was found on the hindlimb muscles, but exclusively on BS muscles. The effects of homatropine (25, 50, 100 and 200 microg), an acetylcholine muscarinic receptor antagonist, were tested in 21 rats after UGR was elicited three times at low stimulation intensity (7 mm Hg). Homatropine produced two effects: (i) A significant increase in the latency of UGR. (ii) A facilitation of UGR inhibition. In view of these results it can be speculated that muscarinic receptor stimulation is involved in the elicitation of UGR.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Homatropine methylbromide Muscarinic acetylcholine receptor M1 Protein Humans YesAntagonistDetails Homatropine methylbromide Muscarinic acetylcholine receptor M2 Protein Humans YesAntagonistDetails Homatropine methylbromide Muscarinic acetylcholine receptor M3 Protein Humans YesAntagonistDetails