Structural biology of hepatitis C virus.

Article Details


Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM

Structural biology of hepatitis C virus.

Hepatology. 2004 Jan;39(1):5-19.

PubMed ID
14752815 [ View in PubMed

Hepatitis C virus (HCV) causes acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Studies of this virus have been hampered by the lack of a productive cell culture system; most information thus has been obtained from analysis of the HCV genome, heterologous expression systems, in vitro and in vivo models, and structural analyses. Structural analyses of HCV components provide an essential framework for understanding of the molecular mechanisms of HCV polyprotein processing, RNA replication, and virion assembly and may contribute to a better understanding of the pathogenesis of hepatitis C. Moreover, these analyses should allow the identification of novel targets for antiviral intervention and development of new strategies to prevent and combat viral hepatitis. This article reviews the current knowledge of HCV structural biology.

DrugBank Data that Cites this Article

NameUniProt ID
Genome polyproteinP26662Details
Genome polyproteinP26663Details
Genome polyproteinP26660Details
Genome polyproteinP26664Details
Genome polyproteinQ9WMX2Details
Genome polyproteinP27958Details
Genome polyproteinP26661Details