The complete genome sequence of the gastric pathogen Helicobacter pylori.

Article Details


Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC

The complete genome sequence of the gastric pathogen Helicobacter pylori.

Nature. 1997 Aug 7;388(6642):539-47.

PubMed ID
9252185 [ View in PubMed

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

DrugBank Data that Cites this Article

NameUniProt ID
3-dehydroquinate dehydrataseQ48255Details
NH(3)-dependent NAD(+) synthetaseO25096Details
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIO24990Details
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseO25927Details
Chorismate synthaseP56122Details
ATP-dependent Clp protease ATP-binding subunit ClpXO25926Details
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZO25928Details
Oxygen-insensitive NADPH nitroreductaseO25608Details