The complete genome sequence of the gastric pathogen Helicobacter pylori.

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Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC

The complete genome sequence of the gastric pathogen Helicobacter pylori.

Nature. 1997 Aug 7;388(6642):539-47.

PubMed ID

9252185 [ View in PubMed

]

Abstract

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

DrugBank Data that Cites this Article

Polypeptides

Name	UniProt ID
3-dehydroquinate dehydratase	Q48255	Details
NH(3)-dependent NAD(+) synthetase	O25096	Details
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	O24990	Details
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase	O25927	Details
Catalase	P77872	Details
Chorismate synthase	P56122	Details
ATP-dependent Clp protease ATP-binding subunit ClpX	O25926	Details
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ	O25928	Details
Oxygen-insensitive NADPH nitroreductase	O25608	Details