Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme.
Article Details
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Zhou DQ, Hu Y, Liu G, Gong L, Xi Y, Wen L
Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme.
Br J Sports Med. 2006 Dec;40(12):988-91. Epub 2006 Sep 25.
- PubMed ID
- 17000714 [ View in PubMed]
- Abstract
OBJECTIVE: To investigate the association between muscle-specific creatine kinase (CKMM) gene polymorphism and the effects of endurance training on running economy. METHODS: 102 biologically unrelated male volunteers from northern China performed a 5000-m running programme, with an intensity of 95-105% ventilatory threshold. The protocol was undertaken three times per week and lasted for 18 weeks. Running economy indexes were determined by making the participants run on a treadmill before and after the protocol, and the A/G polymorphism in the 3' untranslated region of CKMM was detected by polymerase chain reaction-restricted fragment length polymorphism (NcoI restriction enzyme). RESULTS: Three expected genotypes for CKMM-NcoI (AA, AG and GG) were observed in the participants. After training, all running economy indexes declined markedly. Change in steady-state consumption of oxygen, change in steady-state consumption of oxygen by mean body weight, change in steady-state consumption of oxygen by mean lean body weight and change in ventilatory volume in AG groups were larger than those in AA and GG groups. CONCLUSIONS: The findings indicate that the CKMM gene polymorphism may contribute to individual running economy responses to endurance training.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Creatine Creatine kinase M-type Protein Humans YesLigandDetails Phosphocreatine Creatine kinase M-type Protein Humans YesLigandDetails