Alcohol dehydrogenase class-3

BE0000009ProteinHumansADH5

Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). It is acted on by 11 drugs in DrugBank.

Gene name
ADH5
UniProtKB entry
P11766Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
374 residues · 39,724 Da
Also known as
1.1.1.1 · ADHX · Alcohol dehydrogenase 5 · Alcohol dehydrogenase class chi chain · Alcohol dehydrogenase class-III

Resolves to

Protein
UniProtP11766UniProt nameADHX_HUMAN
Gene
HGNCHGNC:253NCBI Gene128GenBank178134GeneCardsADH5
Pharmacology
KEGGhsa:128
Structure
PDB1M6HPDB1M6WPDB1MA0
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alcohol dehydrogenase class-3, how selective are they, and which programs against it are still in active trials?

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