Candesartan cilexetil is an angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy. Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension.
- Mechanism
- Curator reviewed
Candesartan selectively blocks the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. This inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in an overall decrease in blood pressure. Candesartan is greater than 10,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion.
- Primary indication
- May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy.Curator reviewed · 7 structured indications
- Formula / weight
- C33H34N6O6 · 610.671 g/mol (avg)
- First approval
- Canada, 2011 · United States, 1998
- Code names
- SPC3001 · TCV-116
- Brand names
Resolves to
GHOSNRCGJFBJIB-UHFFFAOYSA-NSMILESCCOC1=NC2=C(N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=NN1)C(=CC=C2)C(=O)OC(C)OC(=O)OC1CCCCC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Candesartan cilexetil, and which of those have an active Phase 3 trial?
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