Histamine H4 receptor

BE0000146ProteinHumansHRH4

G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed:26948974). It is acted on by 17 drugs in DrugBank.

Gene name
HRH4
UniProtKB entry
Q9H3N8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
390 residues · 44,495 Da
Also known as
AXOR35 · G protein-coupled receptor 105 · GPCR105 · GPRv53 · H4R

Resolves to

Protein
UniProtQ9H3N8UniProt nameHRH4_HUMAN
Gene
HGNCHGNC:17383NCBI Gene59340GenBank10241847GeneCardsHRH4
Pharmacology
IUPHAR/GtoPdb265KEGGhsa:59340
Structure
PDB7YFCPDB7YFDPDB8HN8
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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60+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histamine H4 receptor, how selective are they, and which programs against it are still in active trials?

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