Monocarboxylate transporter 8

BE0000178ProteinHumansSLC16A2

Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. It is acted on by 7 drugs in DrugBank.

Gene name
SLC16A2
UniProtKB entry
P36021Swiss-Prot
Cellular location
Cell membrane
Residues / weight
539 residues · 59,511 Da
Also known as
MCT 7 · MCT 8 · MCT7 · MCT8 · Monocarboxylate transporter 7

Resolves to

Protein
UniProtP36021UniProt nameMOT8_HUMAN
Gene
HGNCHGNC:10923NCBI Gene6567GenBank458255GeneCardsSLC16A2
Pharmacology
KEGGhsa:6567
Structure
PDB8ZKNPDB8ZKOPDB9DWY
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Monocarboxylate transporter 8, how selective are they, and which programs against it are still in active trials?

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