Glutamate dehydrogenase 1, mitochondrial

BE0000180ProteinHumansGLUD1

Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. It is acted on by 7 drugs in DrugBank.

Gene name
GLUD1
UniProtKB entry
P00367Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
558 residues · 61,397 Da
Also known as
1.4.1.3 · GDH 1 · GLUD

Resolves to

Protein
UniProtP00367UniProt nameDHE3_HUMAN
Gene
HGNCHGNC:4335NCBI Gene2746GenBank31707GeneCardsGLUD1
Pharmacology
KEGGhsa:2746
Structure
PDB1L1FPDB1NR1PDB6DQG
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate dehydrogenase 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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