cGMP-specific 3',5'-cyclic phosphodiesterase

BE0000182ProteinHumansPDE5A

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. It is acted on by 35 drugs in DrugBank.

Gene name
PDE5A
UniProtKB entry
O76074Swiss-Prot
Residues / weight
875 residues · 99,984 Da
Also known as
3.1.4.35 · CGB-PDE · cGMP-binding cGMP-specific phosphodiesterase · PDE5

Resolves to

Protein
UniProtO76074UniProt namePDE5A_HUMAN
Gene
HGNCHGNC:8784NCBI Gene8654GenBank3420185GeneCardsPDE5A
Pharmacology
IUPHAR/GtoPdb1304KEGGhsa:8654
Structure
PDB1RKPPDB1T9RPDB1T9S
Drugs

What you can answer from here — as of September 07, 2019

35DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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149+ReferencesStructured and connected to the statements they support
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Which approved drugs act on cGMP-specific 3',5'-cyclic phosphodiesterase, how selective are they, and which programs against it are still in active trials?

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