17-beta-hydroxysteroid dehydrogenase type 1

BE0000194ProteinHumansHSD17B1

Favors the reduction of estrogens and androgens. It is acted on by 16 drugs in DrugBank.

Gene name
HSD17B1
UniProtKB entry
P14061Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
328 residues · 34,950 Da
Also known as
1.1.1.51 · 17-beta-HSD 1 · 20 alpha-hydroxysteroid dehydrogenase · 20-alpha-HSD · E17KSR

Resolves to

Protein
UniProtP14061UniProt nameDHB1_HUMAN
Gene
HGNCHGNC:5210NCBI Gene3292GenBank23365GeneCardsHSD17B1
Pharmacology
KEGGhsa:3292
Structure
PDB1A27PDB1BHSPDB1DHT
Drugs

What you can answer from here — as of September 03, 2024

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 17-beta-hydroxysteroid dehydrogenase type 1, how selective are they, and which programs against it are still in active trials?

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