Plasminogen activator inhibitor 1
Details
- Name
- Plasminogen activator inhibitor 1
- Kind
- protein
- Synonyms
- Endothelial plasminogen activator inhibitor
- PAI
- PAI-1
- PAI1
- PLANH1
- Serpin E1
- Gene Name
- SERPINE1
- UniProtKB Entry
- P05121Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0000479|Plasminogen activator inhibitor 1 MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
- Number of residues
- 402
- Molecular Weight
- 45059.695
- Theoretical pI
- 7.22
- GO Classification
- Functionsprotease binding / serine-type endopeptidase inhibitor activityProcessesangiogenesis / cellular response to lipopolysaccharide / defense response to Gram-negative bacterium / fibrinolysis / negative regulation of blood coagulation / negative regulation of cell adhesion mediated by integrin / negative regulation of cell migration / negative regulation of endopeptidase activity / negative regulation of endothelial cell apoptotic process / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / negative regulation of fibrinolysis / negative regulation of plasminogen activation / negative regulation of smooth muscle cell migration / negative regulation of smooth muscle cell-matrix adhesion / negative regulation of vascular wound healing / negative regulation of wound healing / positive regulation of angiogenesis / positive regulation of blood coagulation / positive regulation of inflammatory response / positive regulation of interleukin-8 production / positive regulation of leukotriene production involved in inflammatory response / positive regulation of monocyte chemotaxis / positive regulation of receptor-mediated endocytosisComponentsextracellular exosome / extracellular region / extracellular space / plasma membrane / platelet alpha granule lumen
- General Function
- Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084)
- Specific Function
- protease binding
- Pfam Domain Function
- Serpin (PF00079)
- Signal Regions
- 1-23
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010214|Plasminogen activator inhibitor 1 (SERPINE1) ATGCAGATGTCTCCAGCCCTCACCTGCCTAGTCCTGGGCCTGGCCCTTGTCTTTGGTGAA GGGTCTGCTGTGCACCATCCCCCATCCTACGTGGCCCACCTGGCCTCAGACTTCGGGGTG AGGGTGTTTCAGCAGGTGGCGCAGGCCTCCAAGGACCGCAACGTGGTTTTCTCACCCTAT GGGGTGGCCTCGGTGTTGGCCATGCTCCAGCTGACAACAGGAGGAGAAACCCAGCAGCAG ATTCAAGCAGCTATGGGATTCAAGATTGATGACAAGGGCATGGCCCCCGCCCTCCGGCAT CTGTACAAGGAGCTCATGGGGCCATGGAACAAGGATGAGATCAGCACCACAGACGCGATC TTCGTCCAGCGGGATCTGAAGCTGGTCCAGGGCTTCATGCCCCACTTCTTCAGGCTGTTC CGGAGCACGGTCAAGCAAGTGGACTTTTCAGAGGTGGAGAGAGCCAGATTCATCATCAAT GACTGGGTGAAGACACACACAAAAGGTATGATCAGCAACTTGCTTGGGAAAGGAGCCGTG GACCAGCTGACACGGCTGGTGCTGGTGAATGCCCTCTACTTCAACGGCCAGTGGAAGACT CCCTTCCCCGACTCCAGCACCCACCGCCGCCTCTTCCACAAATCAGACGGCAGCACTGTC TCTGTGCCCATGATGGCTCAGACCAACAAGTTCAACTATACTGAGTTCACCACGCCCGAT GGCCATTACTACGACATCCTGGAACTGCCCTACCACGGGGACACCCTCAGCATGTTCATT GCTGCCCCTTATGAAAAAGAGGTGCCTCTCTCTGCCCTCACCAACATTCTGAGTGCCCAG CTCATCAGCCACTGGAAAGGCAACATGACCAGGCTGCCCCGCCTCCTGGTTCTGCCCAAG TTCTCCCTGGAGACTGAAGTCGACCTCAGGAAGCCCCTAGAGAACCTGGGAATGACCGAC ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCCTCTCCACGTC GCGCAGGCGCTGCAGAAAGTGAAGATCGAGGTGAACGAGAGTGGCACGGTGGCCTCCTCA TCCACAGCTGTCATAGTCTCAGCCCGCATGGCCCCCGAGGAGATCATCATGGACAGACCC TTCCTCTTTGTGGTCCGGCACAACCCCACAGGAACAGTCCTTTTCATGGGCCAAGTGATG GAACCCTGA
- Chromosome Location
- 7
- Locus
- 7q22.1
- External Identifiers
Resource Link UniProtKB ID P05121 UniProtKB Entry Name PAI1_HUMAN GenBank Protein ID 35272 GenBank Gene ID X04429 GeneCard ID SERPINE1 GenAtlas ID SERPINE1 HGNC ID HGNC:8583 PDB ID(s) 1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 4G8O, 4G8R, 4IC0, 5BRR, 5ZLZ, 6GWN, 6GWP, 6GWQ, 6I8S, 6ZRV, 7AQF, 7AQG, 9PAI KEGG ID hsa:5054 NCBI Gene ID 5054 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Drotrecogin alfa approved, investigational, withdrawn unknown target Details Urokinase approved, investigational, withdrawn yes target substrateinducer Details Tenecteplase approved unknown target Details Troglitazone approved, investigational, withdrawn unknown target antagonist Details Fibrinolysin investigational unknown target Details Alteplase approved, investigational unknown target Details Anistreplase approved unknown target Details Reteplase approved, investigational unknown target Details Copper approved, investigational unknown target Details TM5614 investigational unknown target Details Colforsin experimental, investigational unknown target inhibitor Details Bucladesine experimental unknown target inhibitor Details Aleplasinin investigational yes target inhibitor Details