Thiorphan

DB08626ExperimentalSmall molecule

A potent inhibitor of membrane metalloendopeptidase (enkephalinase). Thiorphan potentiates morphine-induced analgesia and attenuates naloxone-precipitated withdrawal symptoms.

Mechanism: Pharmacologically active on Neprilysin
Curator reviewed
Formula / weight: C₁₂H₁₅NO₃S · 253.317 g/mol (avg)

Resolves to

Compound

UNIIXJ8Z52GK3XCAS76721-89-6ChEMBLCHEMBL298827PubChem4369380KEGGC01619

Structure

InChIKeyLJJKNPQAGWVLDQ-SNVBAGLBSA-NSMILES[H][C@](CS)(CC1=CC=CC=C1)C(=O)NCC(O)=O

Targets

P08473MME

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Thiorphan, and which of those have an active Phase 3 trial?

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