Vitamin K-dependent gamma-carboxylase

BE0000403ProteinHumansGGCX

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide (PubMed:17073445, PubMed:39880952, PubMed:39880037). It is acted on by 8 drugs in DrugBank.

Gene name
GGCX
UniProtKB entry
P38435Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
758 residues · 87,560 Da
Also known as
4.1.1.90 · Gamma-glutamyl carboxylase · GC · Peptidyl-glutamate 4-carboxylase · Vitamin K gamma glutamyl carboxylase

Resolves to

Protein
UniProtP38435UniProt nameVKGC_HUMAN
Gene
HGNCHGNC:4247NCBI Gene2677GenBank184028GeneCardsGGCX
Pharmacology
KEGGhsa:2677
Structure
PDB9BUMPDB9BURPDB9BUX
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vitamin K-dependent gamma-carboxylase, how selective are they, and which programs against it are still in active trials?

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