RAC-alpha serine/threonine-protein kinase

BE0000428ProteinHumansAKT1

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960,... It is acted on by 33 drugs in DrugBank.

Gene name
AKT1
UniProtKB entry
P31749Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
480 residues · 55,686 Da
Also known as
2.7.11.1 · PKB · PKB alpha · Protein kinase B · Protein kinase B alpha

Resolves to

Protein
UniProtP31749UniProt nameAKT1_HUMAN
Gene
HGNCHGNC:391NCBI Gene207GenBank190828GeneCardsAKT1
Pharmacology
IUPHAR/GtoPdb1479KEGGhsa:207
Structure
PDB1H10PDB1UNPPDB1UNQ
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
31Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
61GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
139+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on RAC-alpha serine/threonine-protein kinase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In