Tyrosine-protein kinase ABL2

BE0000435ProteinHumansABL2

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. It is acted on by 9 drugs in DrugBank.

Gene name
ABL2
UniProtKB entry
P42684Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
1,182 residues · 128,342 Da
Also known as
2.7.10.2 · Abelson murine leukemia viral oncogene homolog 2 · Abelson tyrosine-protein kinase 2 · Abelson-related gene protein · ABLL

Resolves to

Protein
UniProtP42684UniProt nameABL2_HUMAN
Gene
HGNCHGNC:77NCBI Gene27GenBank178993GeneCardsABL2
Pharmacology
IUPHAR/GtoPdb1924KEGGhsa:27
Structure
PDB2ECDPDB2KK1PDB2XYN
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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25GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase ABL2, how selective are they, and which programs against it are still in active trials?

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