Branched-chain-amino-acid aminotransferase, cytosolic

BE0000517ProteinHumansBCAT1

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. It is acted on by 8 drugs in DrugBank.

Gene name
BCAT1
UniProtKB entry
P54687Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
386 residues · 42,966 Da
Also known as
2.6.1.42 · BCAT(c) · BCT1 · ECA39

Resolves to

Protein
UniProtP54687UniProt nameBCAT1_HUMAN
Gene
HGNCHGNC:976NCBI Gene586GenBank1036780GeneCardsBCAT1
Pharmacology
IUPHAR/GtoPdb3210KEGGhsa:586
Structure
PDB2ABJPDB2COGPDB2COI
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Branched-chain-amino-acid aminotransferase, cytosolic, how selective are they, and which programs against it are still in active trials?

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