Guanidinoacetate N-methyltransferase

BE0000567ProteinHumansGAMT

Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:24415674, PubMed:26003046, PubMed:26319512). It is acted on by 5 drugs in DrugBank.

Gene name
GAMT
UniProtKB entry
Q14353Swiss-Prot
Residues / weight
236 residues · 26,318 Da
Also known as
2.1.1.2

Resolves to

Protein
UniProtQ14353UniProt nameGAMT_HUMAN
Gene
HGNCHGNC:4136NCBI Gene2593GenBank1212946GeneCardsGAMT
Pharmacology
KEGGhsa:2593
Structure
PDB3ORH
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanidinoacetate N-methyltransferase, how selective are they, and which programs against it are still in active trials?

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