Aminodeoxychorismate synthase component 1

BE0000597ProteinEscherichia coli (strain K12)pabB

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. It is acted on by 1 drug in DrugBank.

Gene name
pabB
UniProtKB entry
P05041Swiss-Prot
Residues / weight
453 residues · 50,969 Da
Also known as
2.6.1.85 · 4-amino-4-deoxychorismate synthase component 1 · ADC synthase

Resolves to

Protein
UniProtP05041UniProt namePABB_ECOLI
Gene
NCBI Gene946337GenBank147058
Pharmacology
KEGGecj:JW1801
Structure
PDB1K0EPDB1K0G
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aminodeoxychorismate synthase component 1, how selective are they, and which programs against it are still in active trials?

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