Heme oxygenase 1

BE0000735ProteinHumansHMOX1

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). It is acted on by 19 drugs in DrugBank.

Gene name
HMOX1
UniProtKB entry
P09601Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
288 residues · 32,818 Da
Also known as
1.14.14.18 · HO · HO-1 · HO1

Resolves to

Protein
UniProtP09601UniProt nameHMOX1_HUMAN
Gene
HGNCHGNC:5013NCBI Gene3162GenBank35173GeneCardsHMOX1
Pharmacology
IUPHAR/GtoPdb1441KEGGhsa:3162
Structure
PDB1N3UPDB1N45PDB1NI6
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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30GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Heme oxygenase 1, how selective are they, and which programs against it are still in active trials?

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