Phenylalanine-4-hydroxylase

BE0000753ProteinHumansPAH

Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. It is acted on by 13 drugs in DrugBank.

Gene name
PAH
UniProtKB entry
P00439Swiss-Prot
Residues / weight
452 residues · 51,862 Da
Also known as
1.14.16.1 · PAH · Phe-4-monooxygenase

Resolves to

Protein
UniProtP00439UniProt namePH4H_HUMAN
Gene
HGNCHGNC:8582NCBI Gene5053GenBank189937GeneCardsPAH
Pharmacology
IUPHAR/GtoPdb1240KEGGhsa:5053
Structure
PDB1DMWPDB1J8TPDB1J8U
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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14Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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93+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phenylalanine-4-hydroxylase, how selective are they, and which programs against it are still in active trials?

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