Vitamin D3 receptor

BE0000779ProteinHumansVDR

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). It is acted on by 32 drugs in DrugBank.

Gene name
VDR
UniProtKB entry
P11473Swiss-Prot
Cellular location
Nucleus
Residues / weight
427 residues · 48,289 Da
Also known as
1,25-dihydroxyvitamin D3 receptor · NR1I1 · Nuclear receptor subfamily 1 group I member 1 · VDR

Resolves to

Protein
UniProtP11473UniProt nameVDR_HUMAN
Gene
HGNCHGNC:12679NCBI Gene7421GenBank340203GeneCardsVDR
Pharmacology
IUPHAR/GtoPdb605KEGGhsa:7421
Structure
PDB1DB1PDB1IE8PDB1IE9
Drugs

What you can answer from here — as of September 07, 2019

32DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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135+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vitamin D3 receptor, how selective are they, and which programs against it are still in active trials?

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