Nicotinamide N-methyltransferase

BE0000783ProteinHumansNNMT

Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). It is acted on by 3 drugs in DrugBank.

Gene name
NNMT
UniProtKB entry
P40261Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
264 residues · 29,574 Da
Also known as
2.1.1.1

Resolves to

Protein
UniProtP40261UniProt nameNNMT_HUMAN
Gene
HGNCHGNC:7861NCBI Gene4837GenBank494989GeneCardsNNMT
Pharmacology
IUPHAR/GtoPdb3205KEGGhsa:4837
Structure
PDB21JXPDB21LNPDB21NJ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nicotinamide N-methyltransferase, how selective are they, and which programs against it are still in active trials?

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