Maleylacetoacetate isomerase

BE0000819ProteinHumansGSTZ1

Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. It is acted on by 5 drugs in DrugBank.

Gene name
GSTZ1
UniProtKB entry
O43708Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
216 residues · 24,212 Da
Also known as
5.2.1.2 · Glutathione S-transferase zeta 1 · GSTZ1-1 · MAAI

Resolves to

Protein
UniProtO43708UniProt nameMAAI_HUMAN
Gene
HGNCHGNC:4643NCBI Gene2954GenBank2832731GeneCardsGSTZ1
Pharmacology
KEGGhsa:2954
Structure
PDB1FW1PDB8E8P
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Maleylacetoacetate isomerase, how selective are they, and which programs against it are still in active trials?

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