Platelet-derived growth factor receptor alpha

BE0000852ProteinHumansPDGFRA

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. It is acted on by 33 drugs in DrugBank.

Gene name
PDGFRA
UniProtKB entry
P16234Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,089 residues · 122,668 Da
Also known as
2.7.10.1 · Alpha platelet-derived growth factor receptor · Alpha-type platelet-derived growth factor receptor · CD140 antigen-like family member A · CD140a antigen

Resolves to

Protein
UniProtP16234UniProt namePGFRA_HUMAN
Gene
HGNCHGNC:8803NCBI Gene5156GenBank189734GeneCardsPDGFRA
Pharmacology
IUPHAR/GtoPdb1803KEGGhsa:5156
Structure
PDB1GQ5PDB5GRNPDB5K5X
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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43Clinical trialsTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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127+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Platelet-derived growth factor receptor alpha, how selective are they, and which programs against it are still in active trials?

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