Sulfotransferase 1A1

BE0000927ProteinHumansSULT1A1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. It is acted on by 12 drugs in DrugBank.

Gene name
SULT1A1
UniProtKB entry
P50225Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
295 residues · 34,165 Da
Also known as
2.8.2.1 · Aryl sulfotransferase 1 · HAST1/HAST2 · P-PST 1 · Phenol sulfotransferase 1

Resolves to

Protein
UniProtP50225UniProt nameST1A1_HUMAN
Gene
HGNCHGNC:11453NCBI Gene6817GenBank179042GeneCardsSULT1A1
Pharmacology
KEGGhsa:6817
Structure
PDB1LS6PDB1Z28PDB2D06
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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9Metabolic reactionsDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sulfotransferase 1A1, how selective are they, and which programs against it are still in active trials?

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